Top 7 immunology papers

A snapshot of the most highly ranked articles in immunology, from Faculty of 1000

Jef Akst
Jef Akst

Jef Akst is managing editor of The Scientist, where she started as an intern in 2009 after receiving a master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses.

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linkurl:1. New clue to self-tolerance; Researchers identify a new population of regulatory T cells, important players in immunological self-tolerance, which can be induced by cytokine interleukin IL-35. These iTr35 cells, which can themselves make IL-35 and initiate the production of more iTr35 cells, can suppress and regulate immune responses in a variety of pathogenic models in mice, opening up a new direction in immunology research and presenting possible therapeutic implications.L. W. Collison, et al., "IL-35-mediated induction of a potent regulatory T cell population," linkurl:Nat Immunol,; 2010. Evaluated by Stephen Cobbold, University of Oxford; Stanley Perlman, University of Iowa. linkurl:Free F1000 Evaluation;
Neutrophil immune cell engulfing anthrax bacteria
Image: Wikimedia commons, Etxrge
linkurl:2. Another route to helper T; T helper 17 cells, which are crucial for host defense and autoimmunity, can differentiate in the absence of TGF-β signaling, contrary to conventional wisdom on Th17 differentiation. Th17 cells derived without...
K. Ghoreschi, et al., "Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling," linkurl:Nature,; 467:967-71, 2010. Evaluated by: Wuzhou Wan and Philip Murphy, National Institute of Allergy and Infectious Diseases; Jeremy McAleer and Jay Kolls, Lousianna State University Health Sciences Centre; Robert Booth, Virobay Inc. linkurl:Free F1000 Evaluation; linkurl:3. Natural killer cells adapt, too; S. Paust, et al., "Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses," linkurl:Nat Immunol,; 2010. Evaluated by: Sumi Rajagopalan and Eric Long, National Institute of Allergy and Infectious Diseases; Eric Vivier, Centre d'Immunologie de Marseille-Luminy. linkurl:Free F1000 Evaluation; linkurl:4. Key differentiation factor elucidated; R. Gandhi, et al., "Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells," linkurl:Nat Immunol,; 11(9):846-53, 2010. Evaluated by: Byron Vaughn, Moritz Schmelzle and Simon Robson, Beth Israel Deaconess Medical Center; Ru Zhou and Rachel Caspi, National Eye Institute, NIH. linkurl:Free F1000 Evaluation; linkurl:5. Avoiding self destruction; H.J. Kim, et al., "Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance," linkurl:Nature,; 467(7313):328-32, 2010. Evaluated by: Takeshi Tsubata, Tokyo Medical and Dental University; Bryce A Binstadt, University of Minnesota. linkurl:Free F1000 Evaluation; linkurl:6. miRNA regulation in immunity; L.F. Lu, et al., "Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses," linkurl:Cell,; 142(6):914-29, 2010. Evaluated by: Astar Winoto, University of California, Berkeley. linkurl:Free F1000 Evaluation; linkurl:7. Complement-mediated asthma; S. Lajoie, et al., "Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma," linkurl:Nat Immunol,; 11(10):928-35, 2010. Evaluated by: Thirumalai Ramalingam and Thomas Wynn, National Institutes of Health; Sarah Gaffen, University of Pittsburgh. linkurl:Free F1000 Evaluation;

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