Top 7 in biochemistry

A snapshot of the most highly ranked articles in biochemistry and related areas, from Faculty of 1000

Cristina Luiggi
Apr 14, 2011
linkurl:1. SWEET proteins found;http://www.f1000biology.com/article/w7k0gdj9cm62gtt/id/6785956 A new class of proteins, dubbed SWEETs, function as glucose transporters, shuttling sugar molecules out of plant, worm and human cells. In some plants, SWEET proteins are co-opted by bacterial pathogens to deliver nutrition to the invaders.L.Q. Chen et al., linkurl:"Sugar transporters for intercellular exchange and nutrition of pathogens,";http://www.ncbi.nlm.nih.gov/sites/entrez/21107422?dopt=Abstract&holding=f1000%2Cf1000m __Nature__, 468:527-32, 2010. Evaluations by Julian Schroeder, UCSD; Akiko Sugio and Saskia Hogenhout, The John Innes Centre, UK; John Patrick, Univ Newcastle, Australia; David Alpers, Wash U Sch of Med; Bruno Stieger, Univ Hosp Zurich; Tapio Palva, Univ Helsinki; H Ekkehard Neuhaus, Univ Kaiserslautern, Germany. linkurl:Free F1000 Evaluation;http://www.f1000biology.com/article/w7k0gdj9cm62gtt/id/6785956 linkurl:2. Identifying the unknown;http://f1000.com/7792962?key=dx0nw38p878tf3l
Image: flickr, AJC1
Researchers present a novel method for identifying antibody biomarkers for diseases without known antigens. The technique, which involves searching for antibodies that bind to various synthetic molecules, may prove useful for identifying diagnostic markers in a wide variety of...
M.M. Reddy, et al., linkurl:"Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening,";http://www.ncbi.nlm.nih.gov/sites/entrez/21215375?dopt=Abstract&holding=f1000%2Cf1000m Cell, 144:132-42, 2011. Evaluated by Angela Vincent, Univ of Oxford, UK; Robert Powers, Univ of Nebraska; Soumitra Ghosh and Kavita Shah, Purdue Univ; Ivan Gerling, Univ Tennessee Health Sci Cen; David Holtzman, Wash Univ School of Med. linkurl:Free F1000 Evaluation;http://f1000.com/7792962?key=dx0nw38p878tf3l linkurl:3. Motor protein visualized;http://f1000.com/8600958?key=rtyxgrcyqfx5f5d A.P. Carter et al., linkurl:"Crystal structure of the dynein motor domain,";http://www.sciencemag.org/content/331/6021/1159.abstract __Science__, 331:1159-65, 2011. Evaluated by Terrence Frey, San Diego State Univ.; Linda Amos, MRC Lab of Molecular Bio, UK; Giampietro Schiavo, Imperial Cancer Research Fund, UK; Sharyn Endow, Duke Univ. Medical Center; Peter Stathopulos and Mitsuhiko Ikura, Ontario Cancer Inst, Canada. linkurl:Free F1000 Evaluation;http://www.f1000biology.com/article/rtyxgrcyqfx5f5d/id/8600958 linkurl:4. Inflammatory scissors;http://f1000.com/9336958?key=dlkmnxj0nhmn7xg G. Xu et al., linkurl:"Crystal structure of inhibitor of kappaB kinase beta,";http://www.nature.com/nature/journal/vaop/ncurrent/full/nature09853.html __Nature__, doi:10.1038/nature09853, 2011. Evaluated by Andrew Beenken and Moosa Mohammadi, NYU Langonne Medical Center; John Kyriakis, Tufts Medical Center. linkurl:Free F1000 Evaluation;http://f1000.com/9336958?key=dlkmnxj0nhmn7xg linkurl:5. Artificial proteins to the rescue;http://f1000.com/8845958?key=yrsvtphqwwxqdjh
Image: flickr, CdePaz
M.A. Fisher et al., linkurl:"De novo designed proteins from a library of artificial sequences function in Escherichia coli and enable cell growth,";http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0015364 __PLoS One__, 6(1):e15364, 2011. Evaluated by Etienne Joly, CNRS, France; Donald Doyle, Georgia Inst of Technology; Ulrich Muller. linkurl:Free F1000 Evaluation;http://f1000.com/8845958?key=yrsvtphqwwxqdjh linkurl:6. Two-timing transporters;http://f1000.com/3884957?key=p9dpsvp1rjdnl82 J.F. Dishinger et al., linkurl:"Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP,";http://www.nature.com/ncb/journal/v12/n7/abs/ncb2073.html __Nat Cell Biol__, 12:703-10, 2011. Evaluated by Yuh Min Chook, Univ of Texas; Monica Bettencourt-Dias, Inst Gulbenkian de Ciencia, Portugal; Michael Rape, Berkeley Univ; Jonathan Bird and Thomas Friedman, NIDCD NIH. linkurl:Free F1000 Evaluation;http://f1000.com/3884957?key=p9dpsvp1rjdnl82 linkurl:7. Epigenome interrupted;http://f1000.com/7436956?key=jkt12jkh7dfw75y
Image: flickr, AJC1
P. Sarkies et al., linkurl:"Epigenetic instability due to defective replication of structured DNA,";http://www.cell.com/molecular-cell/abstract/S1097-2765(10)00847-6 __Mol Cell__, 40:703-13, 2010. Evaluated by Matthew Bochman and Virginia Zakian, Princeton Univ; Alan Lehmann, Univ of Sussex, UK; Antony Carr, Univ of Sussex, UK. linkurl:Free F1000 Evaluation;http://f1000.com/7436956?key=jkt12jkh7dfw75y



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