Top 7 in biochemistry

A snapshot of the most highly ranked articles in biochemistry and related areas, from Faculty of 1000

Jef Akst
Jef Akst

Jef Akst is managing editor of The Scientist, where she started as an intern in 2009 after receiving a master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses.

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Feb 20, 2011
linkurl:1. Eukaryotic ribosome unveiled;http://f1000.com/6750956?key=7x8qmggqblmdt5j
Atomic structure of the 50S large subunit of the ribosome
Image: Wikimedia commons, Vossman
The long-sought crystal structure of the translational machinery in yeast reveals unique interactions within and between the ribosome's two subunits and promises to lead to a better understanding of protein synthesis in eukaryotes. A. Ben-Shem et al., "Crystal structure of the eukaryotic ribosome,"linkurl: Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/21109664?dopt=Abstract&holding=f1000%2Cf1000m 330:1203-09, 2010. Evaluated by Daniel Gallie, UC Riverside; Margaret Elvekrog, Daniel MacDougall and Ruben Gonzalez, Columbia Univ; Robert Batey, Univ. of Colorado at Boulder; Dmitri Ermolenko and George Makhatadze, Rensselaer Polytechnic Institute. linkurl:Free F1000 Evaluation;http://f1000.com/6750956?key=7x8qmggqblmdt5j linkurl:2. Detailing protein dynamics;http://f1000.com/1309961?key=2q37ty2b38b5r8vCombining the classic approaches of ambient temperature X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy, researchers detail the conversion between different states of an enzyme, and how those dynamics affect catalytic activity. J.S. Fraser, et al., "Hidden alternative structures of proline isomerase essential for catalysis,"...
3. The genome shuffleP.J. Stephens, et al., "Massive genomic rearrangement acquired in a single catastrophic event during cancer development," linkurl:Cell,;http://www.ncbi.nlm.nih.gov/sites/entrez/21215367?dopt=Abstract&holding=f1000%2Cf1000m 144:27-40, 2011. Evaluated by Jordi Camps and Thomas Ried, NCI; Yamini Dalal, NCI; Giovanni Neri, Univ Cattolica S Cuore; Robert Booth, Virobay Inc; Yan Xu and Makoto Komiyama, Univ Tokyo. linkurl:Free F1000 Evaluation;http://www.f1000biology.com/article/g79vstgp2slq12q/id/7848958 4. Taming inflammationE. Nicodeme, et al., "Suppression of inflammation by a synthetic histone mimic," linkurl:Nature,;http://www.ncbi.nlm.nih.gov/sites/entrez/21068722?dopt=Abstract&holding=f1000%2Cf1000m 468:1119-23, 2010. Evaluated by Lionel Ivashkiv, Hosp for Special Surgery; Marc Rothenberg, Cincinnati Children's Hosp Med Cen; Xiaodong Cheng, Emory Univ School of Med. linkurl:Free F1000 Evaluation;http://f1000.com/7111956?key=8mfg87mn6kjbrv5 5. Elusive intermediate #1 capturedJ. Rittle and M.T. Green, "Cytochrome P450 compound I: capture, characterization, and C-H bond activation kinetics," linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/21071661?dopt=Abstract&holding=f1000%2Cf1000m 330:933-37, 2010. Evaluated by Elizabeth Gillam, Univ Queensland; Ivo Feussner, Georg August Univ. G?ttingen, Germany; Russ Hille, UC Riverside; Kap-Sun Yeung and Nicholas Meanwell, Bristol Myers Squibb. linkurl:Free F1000 Evaluation;http://f1000.com/6366957?key=rljs9ddcbkgbjcx 6. ATP machine close-upL.K. Lee, et al., "The structure of the peripheral stalk of Thermus thermophilus H+-ATPase/synthase," linkurl:Nat Struct Mol Biol,;http://www.ncbi.nlm.nih.gov/sites/entrez/20173764?dopt=Abstract&holding=f1000%2Cf1000m 17:373-78, 2010. Evaluated by Ingo Grotjohann and Petra Fromme, Arizona State University; E Neil G Marsh, University of Michigan; Thomas Meier, Max Planck Institute of Biophysics; Michael Galperin, NIH; Stephan Wilkens, SUNY Upstate Medical University. linkurl:Free F1000 Evaluation;http://f1000.com/2464957?key=t8hgyx26cwcl0c5 7. Identifying the unknownM.M. Reddy, et al., "Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening," linkurl:Cell,;http://www.ncbi.nlm.nih.gov/sites/entrez/21215375?dopt=Abstract&holding=f1000%2Cf1000m 144:132-42, 2011. Evaluated by Soumitra Ghosh and Kavita Shah, Purdue Univ; Ivan Gerling, Univ Tennessee Health Sci Cen; David Holtzman, Wash Univ School of Med. linkurl:Free F1000 Evaluation;http://f1000.com/7792962?key=dx0nw38p878tf3l



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