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Top 7 in biochemistry

A snapshot of the most highly ranked articles in biochemistry, from Faculty of 1000

Cristina Luiggi
linkurl:1. New moves for myosin;http://f1000.com/6250962?key=wdd8tywq8bcwg4p In order to transport intracellular cargo within a cell, the motor protein myosin V walks along actin filaments by sweeping one of its arms over the other in a series of microscopic steps, researchers confirmed using high-speed atomic force microscopy. This highly detailed, real-time imaging also revealed new features of the myosin walk, such as "stomping," where one of the arms briefly detaches from the actin, and then reattaches in the same spot.N. Kodera et al., linkurl:Nature,;http://www.nature.com/nature/journal/v468/n7320/abs/nature09450.html?lang=en 468:72-6, 2010. Evaluated by Thomas Meier, Max Planck Institute of Biophysics; Yamini Dalal, National Cancer Institute; Fred D Mast and Richard A Rachubinski, Univ. of Alberta; Erik Sahai, Cancer Research UK. linkurl:Free F1000 Evaluation;http://f1000.com/6250962?key=wdd8tywq8bcwg4p linkurl:2. Eukaryotic ribosome unveiled;http://f1000.com/6750956?key=7x8qmggqblmdt5j The long-elusive crystal structure of the translational machinery in yeast reveals unique interactions within and between the ribosome's two subunits and promises to lead to a better understanding of...
A. Ben-Shem et al., linkurl:Science,;http://www.sciencemag.org/content/330/6008/1203.abstract 330:1203-9, 2010. Evaluated by Robert Batey, Univ. of Colorado at Boulder; Dmitri Ermolenko and George Makhatadze, Rensselaer Polytechnic Institute. linkurl:Free F1000 Evaluation;http://f1000.com/6750956?key=7x8qmggqblmdt5j linkurl:3. Elusive intermediate #1 captured;http://f1000.com/6366957?key=rljs9ddcbkgbjcx J. Rittle and M.T. Green, linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/20947758?dopt=Abstract&holding=f1000%2Cf1000m 330:933-7, 2010. Evaluations by Ivo Feussner, Georg August Univ. G?ttingen, Germany; Russ Hille, UC Riverside; Kap-Sun Yeung and Nicholas Meanwell, Bristol Myers Squibb. linkurl:Free F1000 Evaluation;http://f1000.com/6366957?key=rljs9ddcbkgbjcx linkurl:4. Elusive intermediate #2 captured;http://f1000.com/5349956?key=r9p0yh94ttl9jpc D.M. Korzhnev, et al., linkurl:Science,;http://www.sciencemag.org/content/329/5997/1312.abstract 329:1312-6, 2010. Evaluations by Robert Powers, Univ. Nebraska; Mikael Akke, Lund University, Sweden. linkurl:Free F1000 Evaluation;http://f1000.com/5349956?key=r9p0yh94ttl9jpc linkurl:5. Ribosome assembly up close;http://f1000.com/6901956?key=32t9h7nnvsqr6jp A.M. Mulder, et al., linkurl:Science,;http://www.sciencemag.org/content/330/6004/673.abstract 330:673-7, 2010. Evaluations by Pascale Legault, Univ. Montreal; Mikael Akke, Lund University, Sweden. linkurl:Free F1000 Evaluation;http://f1000.com/6901956?key=32t9h7nnvsqr6jp linkurl:6. Growth factor mystery solved;http://f1000.com/5040957?key=p4wy92vjck24jfw D. Alvarado, et al., linkurl:Cell,;http://www.cell.com/abstract/S0092-8674%2810%2900784-1 142:568-79, 2010. Evaluations by Yue Sun and Richard Anderson, Univ. Wisconsin-Madison; Andrew Beenken and Moosa Mohammadi, NYU Langone Medical Center; Arthur Christopoulos, Monash Univ., Australia. linkurl:Free F1000 Evaluation;http://f1000.com/5040957?key=p4wy92vjck24jfw
Malarial sporozoite
Wikimedia commons: image by Ute Frevert
false color by Margaret Shear
linkurl:7. New class of antimalarial agents;http://f1000.com/5063956?key=nsrtydjf70965qk R.A. Oliveira et al., linkurl:Science,;http://www.sciencemag.org/content/329/5996/1175.abstract 329:1175-80, 2010. Evaluations by David Triggle, SUNY at Buffalo; Dominique Soldati, Univ. of Geneva; Karin Romisch, Saarland Univ., Germany. linkurl:Free F1000 Evaluation;http://f1000.com/5063956?key=nsrtydjf70965qk



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