Top 7 in biochemistry

A snapshot of the most highly ranked articles in biochemistry, from Faculty of 1000

Cristina Luiggi
Nov 29, 2010
linkurl:1. New role for non-coding RNA;http://f1000.com/5601958?key=gqh9xf05njf034l Some long non-coding RNAs are required for the expression of neighboring protein-coding genes in humans — yet another role the mysterious non-coding transcriptome plays in regulating gene expression.U.A. Ørom et al., linkurl:Cell,;http://www.ncbi.nlm.nih.gov/sites/entrez/20887892?dopt=Abstract&holding=f1000%2Cf1000m 143:46-58, 2010. Evaluated by Leonie Ringrose, Institute of Molecular Biotechnology; A. Clery, D. Theler, and F. Allain, ETH; J. Abrams, Univ. of Texas Southwestern Medical Center at Dallas; E. Lara-Pezzi and N. Rosenthal, EMBL. linkurl:Free F1000 Evaluation;http://f1000.com/5601958?key=gqh9xf05njf034l
E. coli
Image: Wikimedia commons, NIAID
linkurl:2. It takes three to replicate;http://f1000.com/3176956?key=c2pndjc7fv2tqm0 Using single-molecule fluorescence microscopy, researchers observed for the first time the DNA replication machinery at work in living E. coli cells in real time. The novel technique revealed that DNA replication in the bacterium requires the concerted action of three, and not two (as previously thought), polymerases.R. Reyes-Lamothe et al., linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/20413500?dopt=Abstract&holding=f1000%2Cf1000m 328:498-501, 2010. Evaluated by Martin Marinus, UMass Medical School; Sabine...
linkurl:3. Folding, at atomic-scale;http://f1000.com/5964957?key=4ysrnn7m1b32fzs D.E. Shaw, et al., linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/20947758?dopt=Abstract&holding=f1000%2Cf1000m 330:341-6, 2010. Evaluations by Gottfried Otting, Australian National Univ; Torleif Härd, Swedish Univ. of Agricultural Sciences. linkurl:Free F1000 Evaluation;http://f1000.com/5964957?key=4ysrnn7m1b32fzs linkurl:4. Tricky proteins targeted;http://f1000.com/5551957?key=r1gp8s999h9cpvt J.M. Kee, et al., linkurl:J Am Chem Soc,;http://www.ncbi.nlm.nih.gov/sites/entrez/20879710?dopt=Abstract&holding=f1000%2Cf1000m 132:14327-9, 2010. Evaluations by Michael Gelb, Univ. Washington; Derek Macmillan, Macromolecular Chemistry, UK; Michael Pirrung, UC Riverside. linkurl:Free F1000 Evaluation;http://f1000.com/5551957?key=r1gp8s999h9cpvt linkurl:5. Defense mechanism elucidated;http://f1000.com/5302957?key=141vmd9c3xl6gf2 R.E. Haurwitz, et al., linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/20829488?dopt=Abstract&holding=f1000%2Cf1000m 329:1355-8, 2010. Evaluations by Rachel Senturia and Feng Guo, UCLA; Jim Maher, Mayo Clinic College of Medicine; Robert Batey, U Colorado at Boulder. linkurl:Free F1000 Evaluation;http://f1000.com/5302957?key=141vmd9c3xl6gf2
Heme group B
Image: Wikimedia commons, Ronk01
linkurl:6. How cells traffic heme;http://f1000.com/5629978?key=2j836pdzv4lsxcd R. Chakravarti, et al., linkurl:PNAS,;http://www.ncbi.nlm.nih.gov/sites/entrez/20921417?dopt=Abstract&holding=f1000%2Cf1000m 107:18004-9, 2010. Evaluations by David Wink, National Cancer Institute; Jack Lancaster, U Alabama at Birmingham. linkurl:Free F1000 Evaluation;http://f1000.com/5629978?key=2j836pdzv4lsxcd linkurl:7. Keys to splitting chromosomes;http://f1000.com/1910956?key=yjj6nfwxv4zhzbq R.A. Oliveira et al., linkurl:Nat Cell Bio,;http://www.ncbi.nlm.nih.gov/sites/entrez/20081838?dopt=Abstract&holding=f1000%2Cf1000m 12:185-92, 2010. Evaluations by Tony Maxwell, John Innes Centre, UK; Gennaro D'Urso, U Miami School of Med; Hanna Windecker and Silke Hauf, Max Planck Society. linkurl:Free F1000 Evaluation;http://f1000.com/1910956?key=yjj6nfwxv4zhzbq



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