Top 7 in cancer biology

A snapshot of the most highly ranked articles in cancer biology and related areas, from Faculty of 1000

Jef Akst
Jef Akst

Jef Akst is managing editor of The Scientist, where she started as an intern in 2009 after receiving a master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses.

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linkurl:1. Powerful tension;
Image of mitotic spindle in a human cell: microtubules in green, chromosomes in blue, and kinetochores in red.
Image: Wikimedia commons, Afunguy
Tension stabilizes the attachment of microtubules to kinetochores during cell division in budding yeast, demonstrating how mechanical forces can modulate chromosome movement during replication. B. Akiyoshi, et al., "Tension directly stabilizes reconstituted kinetochore-microtubule attachments," linkurl:Nature,; 468:576-9. 2010. Evaluations by Claire Walczak, Indiana Univ; William Earnshaw, Univ Edinburgh; Raquel Oliveira, Univ Oxford; Yamini Dalal, NCI; Eugenio Marco and Gaudenz Danuser, Harvard Med Sch; Jonathan Millar, Univ Warwick; Iain Cheeseman, MIT. linkurl:Free F1000 Evaluation; linkurl:2. Mitosis mechanism discovered; Researchers identify a new inhibitor of an enzyme that helps control mitosis by suppressing the activity of cyclin-dependent kinase 1, a key regulator of mitotic entry, revealing a completely novel component of the mitotic control system. S. Mochida et al., "Greatwall phosphorylates an inhibitor of protein phosphatase...
linkurl:3. Cancer contagious among cells; K. Al-Nedawi et al., "Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells," linkurl:Nat Cell Biol,,; 10:619-24, 2008. Evaluations by Clotilde Thery, Curie Inst; Michael Gold, Univ British Columbia; Ross Cagan, Mount Sinai Sch of Med; Harald Stenmark, The Norwegian Radium Hosp. linkurl:Free F1000 evaluation; 4 and 5. Mechanism of anti-tumoral drugs unveiledI.E. Wertz et al., "Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7," linkurl:Nature,; 471:110-4, 2011. Evaluated by Laura Diaz Martinez and Duncan Clarke, Univ Minnesota; Loretta Dorstyn and Sharad Kumar, Cen for Cancer Bio. linkurl:Free F1000 evaluation; Inuzuka et al., "SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction," linkurl:Nature,; 471:104-9, 2011. Evaluated by Laura Diaz Martinez and Duncan Clarke, Univ Minnesota; Loretta Dorstyn and Sharad Kumar, Cen for Cancer Bio. linkurl:Free F1000 evaluation; linkurl:6. Supercoiling sister chromatids; J. Baxter et al., "Positive supercoiling of mitotic DNA drives decatenation by topoisomerase II in eukaryotes," linkurl:Science,; 331:1328-32, 2011. Evaluations by Olivier Hyrien, Institut de Biologie de l'ENS, CNRS. linkurl:Free F1000 evaluation; linkurl:7. Preventing ill-placed telomeres; W. Zhang and D. Durocher, "De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks," linkurl:Genes Dev,; 24:502-15, 2010. Evaluations by David Shore, Univ Geneva; Katherine Friedman, Vanderbilt Univ; Yun Wu and Virginia Zakian, Princeton Univ. linkurl:Free F1000 evaluation;

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