linkurl:1. Cytokines, infection blockers;http://f1000.com/8799956?key=fz8tv2xg8np86l0 Patients infected by Candida albicans -- the causative agent of chronic mucocutaneous candidiasis disease (CMCD), an infection of the oral and genital mucosae, skin, and nails -- and possibly Staphylococcus aureus, often have mutations in genes encoding interleukin-17 receptor A (IL-17RA) and IL-17F, suggesting an essential role of these cytokines in protecting against such infections.A. Puel et al., "Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity," linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/21350122?dopt=Abstract&holding=f1000%2Cf1000m 332:65-8, 2011. Evaluated by Dan Conrad, Virginia Commonwealth Univ; Jay Kolls, LSU Health Sciences Cen; Klaus Ley, La Jolla Inst for Allergy & Immunology; Sarah Gaffen, Univ Pitt; Joshua Milner, National Inst of Allergy and Infectious Diseases. linkurl:Free F1000 evaluation;http://f1000.com/8799956?key=fz8tv2xg8np86l0 linkurl:2. AMPK structure revealed;http://f1000.com/9287956?key=lfnwb36yh6w6n0k Researchers detail the crystal structure of AMP-activated protein kinase (AMPK), which helps regulate cell metabolism and has been implicated in diseases such as type 2 diabetes, obesity and...
B. Xiao et al., "Structure of mammalian AMPK and its regulation by ADP," linkurl:Nature,;http://www.ncbi.nlm.nih.gov/sites/entrez/21399626?dopt=Abstract&holding=f1000%2Cf1000m 472:230-33, 2011. Evaluated by Chris Marshall and Mitsuhiko Ikura, Ontario Cancer Inst; Eduardo Rial, CSIC; Paul Clarke, Univ Dundee; John Kyriakis, Tufts Med Cen. linkurl:Free F1000 evaluation;http://f1000.com/9287956?key=lfnwb36yh6w6n0k linkurl:3. New nano-communication?;http://www.the-scientist.com/news/display/57991/
G.P. Dubey and S. Ben-Yehuda, "Intercellular nanotubes mediate bacterial communication," linkurl:Cell,;http://www.ncbi.nlm.nih.gov/sites/entrez/21335240?dopt=Abstract&holding=f1000%2Cf1000m 144:590-600, 2011. Evaluated by Ramanujam Srinivasan, Mithilesh Mishra and Mohan Balasubramanian, National Univ Singapore; Mélanie Hamon and Pascale Cossart, Institut Pasteur; Fabio Bagnoli and Rino Rappuoli, Novartis; Adrian Mehlitz and Roy Gross, Univ Würzburg. linkurl:Free F1000 evaluation;http://f1000.com/8905957?key=7rysr015hg6hgqw linkurl:4. A long-term memory chemical;http://www.f1000biology.com/article/9nwdhhcqp4ttzjx/id/8941962 A. Suzuki, et al., "Astrocyte-neuron lactate transport is required for long-term memory formation," linkurl:Cell,;http://www.ncbi.nlm.nih.gov/sites/entrez/21376239?dopt=Abstract&holding=f1000%2Cf1000m 144:810-23, 2011. Evaluated by James Bamburg, Colo St Univ; David Wolfer, Univ Zurich; Faraz Sultan and David Sweatt, Univ Ala Birmingham; Karl-Peter Giese, King's Coll, UK. linkurl:Free F1000 evaluation;http://www.f1000biology.com/article/9nwdhhcqp4ttzjx/id/8941962 linkurl:5. Selfing RNA?;http://f1000.com/9660956?key=5hgl3f99rcspp74 A. Wochner et al., "Ribozyme-catalyzed transcription of an active ribozyme," linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/21474753?dopt=Abstract&holding=f1000%2Cf1000m 332:209-12, 2011. Evaluated by Yan Xu and Makoto Komiyama, Univ Tokyo; Peter Unrau, Simon Fraser Univ; Niles Lehman, Portland State Univ; Michael Yarus, Univ Colorado at Boulder; William Scott, Univ California at Santa Cruz. linkurl:Free F1000 evaluation;http://f1000.com/9660956?key=5hgl3f99rcspp74 linkurl:6. Molding microtubules;http://www.f1000biology.com/article/qsl27r6mpfjqxfm/id/5378958 C. elegansJ.S. Akella, et al., "MEC-17 is an alpha-tubulin acetyltransferase," linkurl:Nature,;http://www.ncbi.nlm.nih.gov/sites/entrez/20829795?dopt=Abstract&holding=f1000%2Cf1000m 467:218-22, 2010. Evaluated by Carl Victor Lundin and Yanmin Yang, Stanford Univ Sch of Med; Mark Winey, Univ Colo; Hong-Wei Wang, Yale Univ. linkurl:Free F1000 evaluation;http://www.f1000biology.com/article/qsl27r6mpfjqxfm/id/5378958 linkurl:7. Cell division with a twist;http://www.the-scientist.com/news/display/57981/ J. Guizetti et al., "Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments," linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/21310966?dopt=Abstract&holding=f1000%2Cf1000m 331:1616-20, 2011. Evaluated by Martin Lowe, Univ Manchester; Roger Williams, MRC Laboratory of Molecular Biology; Christopher Janetopoulos, Vanderbilt Univ. linkurl:Free F1000 evaluation;http://f1000.com/8432969?key=7shcqjbngjfkjz6
Image: Courtesy of the Ben-Yehuda laboratory
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