linkurl:1. New role for long noncoding RNA;http://f1000.com/9550956?key=30zszyp96xz0vtc By hitching a ride in loops formed by chromosomes, long intergenic noncoding RNAs (lincRNAs) can activate HOXA genes (a family of genes involved in cell patterning) over long ranges -- one of the few known examples of gene activation by lincRNAs.K.C. Wang, et al., "A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression," linkurl:Nature,;http://www.ncbi.nlm.nih.gov/sites/entrez/21423168?dopt=Abstract&holding=f1000%2Cf1000m 472:120-4, 2011. Evaluated by W. Lee Kraus, Univ of Texas; Panagiotis Ntziachristos and Iannis Aifantis, HHMI/New York Univ School of Medicine; Leonie Ringrose, Inst of Molecular Biotechnology GmbH, Austria; Pamela Geyer, Univ of Iowa. linkurl:Free F1000 Evaluation;http://f1000.com/9550956?key=30zszyp96xz0vtc
linkurl:2. Separating chromosomes;http://f1000.com/2588956?key=mz7cz8hry168gmnFor chromosomes to properly segregate during cell division, the spindle microtubules must be properly attached to protein complexes called kinetochores. The cell regulates...
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microtubules (green), chromosomes (blue), and kinetochores (red). Image: Afunguy, Wikipedia |
D. Liu, et al., "Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase1," linkurl:J Cell Biol,;http://www.ncbi.nlm.nih.gov/sites/entrez/20231380?dopt=Abstract&holding=f1000%2Cf1000m 188:809-20, 2011. Evaluated by Tomoyuki Tanaka, Univ of Dundee, UK; Stefan Westermann, Research Institute of Molecular Pathology, Austria; Laura Trinkle-Mulcahy. Univ of Ottawa, Canada; Vincent Vanoosthuyse and Kevin Hardwick, Univ of Edinburgh, UK. linkurl:Free F1000 Evaluation;http://f1000.com/2588956?key=mz7cz8hry168gmn 3. Erasing stress in plantsH. Ito, et al., "An siRNA pathway prevents transgenerational retrotransposition in plants subjected to stress," linkurl:Nature,;http://www.ncbi.nlm.nih.gov/sites/entrez/21399627?dopt=Abstract&holding=f1000%2Cf1000m 6472:115-9, 2011. Evaluated by Robert Sablowski, John Innes Centre, UK; Renate Schmidt, IPK Gatersleben, Germany; Ian Henderson, Univ of Cambridge, UK. linkurl:Free F1000 Evaluation;http://f1000.com/9256956?key=psqcdg8355h56z6 4. Golden rules for peer reviewingDG Drubin, "Any jackass can trash a manuscript, but it takes good scholarship to create one (how MBoC promotes civil and constructive peer review)," linkurl:Mol Biol Cell,;http://www.molbiolcell.org/cgi/content/full/22/5/525 22:525-7, 2011. Evaluated by Etienne Joly, CNRS, France; Ferdinando Boero, Universita' del Salento, Italy; Gerald Zamponi, Univ of Calgary, Canada; Larry Kane, Univ of Pittsburgh. linkurl:Free F1000 Evaluation;http://f1000.com/10134960?key=70w5gkxmhhy59y2 5. New role for GLRs
CaenorhabditisE. Michard, et al., "Glutamate receptor-like genes form Ca2+ channels in pollen tubes and are regulated by pistil D-serine," linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/21415319?dopt=Abstract&holding=f1000%2Cf1000m 332:434-7, 2011. Evaluated by Heng-Cheng Hu and Caren Chang, Univ of Maryland; Wagner Araujo and Alisdair Fernie, Max Planck Institute of Molecular Plant Physiology, Germany; Wataru Sakamoto, Okayama Univ, Japan. linkurl:Free F1000 Evaluation;http://f1000.com/10038956?key=wj5z12vnf9rcsxs 6. Plant demethylation revealedJ.U. Guo, et al., "Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain," linkurl:Cell,;http://www.ncbi.nlm.nih.gov/sites/entrez/21496894?dopt=Abstract&holding=f1000%2Cf1000m 145:423-34, 2011. Evaluated by Elisabetta Tabolacci and Giovanni Neri, Universit? Cattolica del S Cuore, Italy; Faraz Sultan and David Sweatt, Univ of Alabama at Birmingham. linkurl:Free F1000 Evaluation;http://f1000.com/9919956?key=1fkdlk643qrvt85 7. Death regulators in plantsN.S. Coll, et al., "Arabidopsis type I metacaspases control cell death," linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/21383129?dopt=Abstract&holding=f1000%2Cf1000m 330:1393-7, 2011. Evaluations by Daniel Gallie, Univ of California; Beno?t Lacroix and Vitaly Citovsky, SUNY at Stony Brook; Alexei Kurakin and Roya Khosravi-Far, Beth Israel Deaconess Medical Center. linkurl:Free F1000 Evaluation;http://f1000.com/7655958?key=jm30q7yk8sckn5s
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Flickr/ BlueRidgeKitties |
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