Top 7 in genetics and genomics

A snapshot of the most highly ranked articles in genetics and genomics, from Faculty of 1000

Cristina Luiggi
May 23, 2011
linkurl:1. New role for long noncoding RNA;http://f1000.com/9550956?key=30zszyp96xz0vtc By hitching a ride in loops formed by chromosomes, long intergenic noncoding RNAs (lincRNAs) can activate HOXA genes (a family of genes involved in cell patterning) over long ranges -- one of the few known examples of gene activation by lincRNAs.K.C. Wang, et al., "A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression," linkurl:Nature,;http://www.ncbi.nlm.nih.gov/sites/entrez/21423168?dopt=Abstract&holding=f1000%2Cf1000m 472:120-4, 2011. Evaluated by W. Lee Kraus, Univ of Texas; Panagiotis Ntziachristos and Iannis Aifantis, HHMI/New York Univ School of Medicine; Leonie Ringrose, Inst of Molecular Biotechnology GmbH, Austria; Pamela Geyer, Univ of Iowa. linkurl:Free F1000 Evaluation;http://f1000.com/9550956?key=30zszyp96xz0vtc
Mitotic spindle in a human cell showing
microtubules (green), chromosomes (blue),
and kinetochores (red).

Image: Afunguy, Wikipedia
linkurl:2. Separating chromosomes;http://f1000.com/2588956?key=mz7cz8hry168gmnFor chromosomes to properly segregate during cell division, the spindle microtubules must be properly attached to protein complexes called kinetochores. The cell regulates...
D. Liu, et al., "Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase1," linkurl:J Cell Biol,;http://www.ncbi.nlm.nih.gov/sites/entrez/20231380?dopt=Abstract&holding=f1000%2Cf1000m 188:809-20, 2011. Evaluated by Tomoyuki Tanaka, Univ of Dundee, UK; Stefan Westermann, Research Institute of Molecular Pathology, Austria; Laura Trinkle-Mulcahy. Univ of Ottawa, Canada; Vincent Vanoosthuyse and Kevin Hardwick, Univ of Edinburgh, UK. linkurl:Free F1000 Evaluation;http://f1000.com/2588956?key=mz7cz8hry168gmn 3. Erasing stress in plantsH. Ito, et al., "An siRNA pathway prevents transgenerational retrotransposition in plants subjected to stress," linkurl:Nature,;http://www.ncbi.nlm.nih.gov/sites/entrez/21399627?dopt=Abstract&holding=f1000%2Cf1000m 6472:115-9, 2011. Evaluated by Robert Sablowski, John Innes Centre, UK; Renate Schmidt, IPK Gatersleben, Germany; Ian Henderson, Univ of Cambridge, UK. linkurl:Free F1000 Evaluation;http://f1000.com/9256956?key=psqcdg8355h56z6 4. Golden rules for peer reviewingDG Drubin, "Any jackass can trash a manuscript, but it takes good scholarship to create one (how MBoC promotes civil and constructive peer review)," linkurl:Mol Biol Cell,;http://www.molbiolcell.org/cgi/content/full/22/5/525 22:525-7, 2011. Evaluated by Etienne Joly, CNRS, France; Ferdinando Boero, Universita' del Salento, Italy; Gerald Zamponi, Univ of Calgary, Canada; Larry Kane, Univ of Pittsburgh. linkurl:Free F1000 Evaluation;http://f1000.com/10134960?key=70w5gkxmhhy59y2 5. New role for GLRs
Arabidopsis thaliana seedling
Flickr/ BlueRidgeKitties
CaenorhabditisE. Michard, et al., "Glutamate receptor-like genes form Ca2+ channels in pollen tubes and are regulated by pistil D-serine," linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/21415319?dopt=Abstract&holding=f1000%2Cf1000m 332:434-7, 2011. Evaluated by Heng-Cheng Hu and Caren Chang, Univ of Maryland; Wagner Araujo and Alisdair Fernie, Max Planck Institute of Molecular Plant Physiology, Germany; Wataru Sakamoto, Okayama Univ, Japan. linkurl:Free F1000 Evaluation;http://f1000.com/10038956?key=wj5z12vnf9rcsxs 6. Plant demethylation revealedJ.U. Guo, et al., "Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain," linkurl:Cell,;http://www.ncbi.nlm.nih.gov/sites/entrez/21496894?dopt=Abstract&holding=f1000%2Cf1000m 145:423-34, 2011. Evaluated by Elisabetta Tabolacci and Giovanni Neri, Universit? Cattolica del S Cuore, Italy; Faraz Sultan and David Sweatt, Univ of Alabama at Birmingham. linkurl:Free F1000 Evaluation;http://f1000.com/9919956?key=1fkdlk643qrvt85 7. Death regulators in plantsN.S. Coll, et al., "Arabidopsis type I metacaspases control cell death," linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/21383129?dopt=Abstract&holding=f1000%2Cf1000m 330:1393-7, 2011. Evaluations by Daniel Gallie, Univ of California; Beno?t Lacroix and Vitaly Citovsky, SUNY at Stony Brook; Alexei Kurakin and Roya Khosravi-Far, Beth Israel Deaconess Medical Center. linkurl:Free F1000 Evaluation;http://f1000.com/7655958?key=jm30q7yk8sckn5s



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