linkurl:1. Telomeres to the rescue;http://f1000.com/8034956?key=25rmdn6jylc0hvj
The shortening of telomeres is associated with aging-dependent tissue degeneration, stem cell depletion, and organ failure. By reactivating telomerase and lengthening telomeres in old, telomerase-deficient mice, the degeneration processes can be reversed, restoring damaged tissues to almost full functionality.M. Jaskelioff, et al., "Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice," linkurl:Nature,;http://www.ncbi.nlm.nih.gov/sites/entrez/21113150?dopt=Abstract&holding=f1000%2Cf1000m 469:102-6, 2011. Evaluations by Igor Kogut and John Cambier, National Jewish Med and Research Center; Charles Streuli, Univ of Manchester; William Hahn, Dana Farber Cancer Inst; Preston Estep and Martha Bulyk, Brigham and Women's Hosp, Harvard Med School; Tobias Dansen and Boudewijn Burgering, Univ of Utrecht. linkurl:Free F1000 Evaluation;http://f1000.com/8034956?key=25rmdn6jylc0hvj linkurl:2. Meet the ribosome;http://f1000.com/7710956?key=ldqbgkpn56d0hzzFor the first time, researchers detail the crystal structure of the smaller, 40S subunit of the eukaryotic ribosome. The structure reveals the...
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Image: Wikimedia commons |
J. Rabl et al., "Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1," linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/21205638?dopt=Abstract&holding=f1000%2Cf1000m 331:730-6, 2011. Evaluations by Daniel Gallie, Univ of California; Daniel Wilson, Ludwig Maximilian Univ Munich. linkurl:Free F1000 Evaluation;http://f1000.com/7710956?key=ldqbgkpn56d0hzz 3. Cellular cross-talkE. Sahin, et al., "Telomere dysfunction induces metabolic and mitochondrial compromise," linkurl:Nature,;http://www.ncbi.nlm.nih.gov/sites/entrez/21307849?dopt=Abstract&holding=f1000%2Cf1000m 470:359-65, 2011. Evaluations by Lucio Comai, Keck School of Med, Univ of Southern California; Kevin Conley, Univ of Washington. linkurl:Free F1000 Evaluation;http://www.f1000biology.com/article/2hq17gdd53nmvjf/id/8974956 4. Nucleotide mismatchK. Bebenek, et al., "Replication infidelity via a mismatch with Watson-Crick geometry," linkurl:Proc Natl Acad Sci,;http://www.ncbi.nlm.nih.gov/sites/entrez/21233421?dopt=Abstract&holding=f1000%2Cf1000m 108:1862-7, 2011. Evaluations by Ulrich Hubscher, Univ of Zurich; Rieko Yajima and Katsu Murakami, Pennsylvania State Univ. linkurl:Free F1000 Evaluation;http://f1000.com/8228957?key=n7tbn05j3mbk1r2 5. DNA bodyguardsC. Lukas, et al., "53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress," linkurl:Nat Cell Biol,;http://www.ncbi.nlm.nih.gov/sites/entrez/21317883?dopt=Abstract&holding=f1000%2Cf1000m 13:243-53, 2011. Evaluations by Antony Carr, Univ of Sussez; Junjie Chen, Univ of Texas M. D. Anderson Cancer Center. linkurl:Free F1000 Evaluation;http://www.f1000biology.com/article/ytpcg0n1glblstf/id/9007956 6. Dissecting traitsR.D. Bickel, et al., "Composite effects of polymorphisms near multiple regulatory elements create a major-effect QTL," linkurl:PLoS Genet,;http://www.ncbi.nlm.nih.gov/sites/entrez/21249179?dopt=Abstract&holding=f1000%2Cf1000m 7:e1001275, 2011. Evaluations by Deborah Charlesworth, Univ of Edinburgh; Casey McNeil and Stuart Macdonald, Univ of Kansas. linkurl:Free F1000 Evaluation;http://f1000.com/8693960?key=mm1n1v7tqgcj06q 7. Noisy E. coliY. Taniguchi, et al., "Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells," linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/20671182?dopt=Abstract&holding=f1000%2Cf1000m 329:533-8, 2010. Evaluation by Daniel Hebenstreit and Sarah Teichmann, MRC Laboratory of Mol Biol. linkurl:Free F1000 Evaluation;http://f1000.com/5818958?key=09kcrmhk8qh07s6
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