Top 7 in genetics and genomics

A snapshot of the most highly ranked articles in genetics and genomics, from Faculty of 1000

Megan Scudellari
Apr 4, 2011
linkurl:1. Telomeres to the rescue;
Crystal structure of parallel quadruplexes from human telomeric DNA
Image: Wikimedia commons
The shortening of telomeres is associated with aging-dependent tissue degeneration, stem cell depletion, and organ failure. By reactivating telomerase and lengthening telomeres in old, telomerase-deficient mice, the degeneration processes can be reversed, restoring damaged tissues to almost full functionality.M. Jaskelioff, et al., "Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice," linkurl:Nature,; 469:102-6, 2011. Evaluations by Igor Kogut and John Cambier, National Jewish Med and Research Center; Charles Streuli, Univ of Manchester; William Hahn, Dana Farber Cancer Inst; Preston Estep and Martha Bulyk, Brigham and Women's Hosp, Harvard Med School; Tobias Dansen and Boudewijn Burgering, Univ of Utrecht. linkurl:Free F1000 Evaluation; linkurl:2. Meet the ribosome; the first time, researchers detail the crystal structure of the smaller, 40S subunit of the eukaryotic ribosome. The structure reveals the...
J. Rabl et al., "Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1," linkurl:Science,; 331:730-6, 2011. Evaluations by Daniel Gallie, Univ of California; Daniel Wilson, Ludwig Maximilian Univ Munich. linkurl:Free F1000 Evaluation; 3. Cellular cross-talkE. Sahin, et al., "Telomere dysfunction induces metabolic and mitochondrial compromise," linkurl:Nature,; 470:359-65, 2011. Evaluations by Lucio Comai, Keck School of Med, Univ of Southern California; Kevin Conley, Univ of Washington. linkurl:Free F1000 Evaluation; 4. Nucleotide mismatchK. Bebenek, et al., "Replication infidelity via a mismatch with Watson-Crick geometry," linkurl:Proc Natl Acad Sci,; 108:1862-7, 2011. Evaluations by Ulrich Hubscher, Univ of Zurich; Rieko Yajima and Katsu Murakami, Pennsylvania State Univ. linkurl:Free F1000 Evaluation; 5. DNA bodyguardsC. Lukas, et al., "53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress," linkurl:Nat Cell Biol,; 13:243-53, 2011. Evaluations by Antony Carr, Univ of Sussez; Junjie Chen, Univ of Texas M. D. Anderson Cancer Center. linkurl:Free F1000 Evaluation; 6. Dissecting traitsR.D. Bickel, et al., "Composite effects of polymorphisms near multiple regulatory elements create a major-effect QTL," linkurl:PLoS Genet,; 7:e1001275, 2011. Evaluations by Deborah Charlesworth, Univ of Edinburgh; Casey McNeil and Stuart Macdonald, Univ of Kansas. linkurl:Free F1000 Evaluation; 7. Noisy E. coliY. Taniguchi, et al., "Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells," linkurl:Science,; 329:533-8, 2010. Evaluation by Daniel Hebenstreit and Sarah Teichmann, MRC Laboratory of Mol Biol. linkurl:Free F1000 Evaluation;

Interested in reading more?

Become a Member of

Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?