Top 7 in genetics and genomics

A snapshot of the most highly ranked articles in genetics and genomics, from Faculty of 1000

Bob Grant
Bob Grant

Bob Grant is Editor in Chief of The Scientist, where he started in 2007 as a Staff Writer.

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Jan 17, 2011
linkurl:1. How Tregs limit inflammation;http://bit.ly/iT35TCell T-regulatory cells can multiply their numbers by secreting the cytokine interleukin IL-35, which converts the population of T-cells involved in killing (effector T-cells) into regulatory cells that suppress inflammation, providing a new explanation for how inflammation is reeled in after an infection is cleared. L.W. Collison et al., "IL-35-mediated induction of a potent regulatory T cell population," Nat Immunol, 12:1093-101, 2010. Evaluations by Avinash Bhandoola, Univ Penn; Christian Engwerda, Queensland Inst Med Res, Australia; Lieping Chen, Johns Hopkins Univ Sch of Med; David Serreze, The Jackson Lab; Xiaojing Ma, Weill Med Coll of Cornell Univ; Stephen Cobbold, Univ Oxford; Stanley Perlman, Univ Iowa. linkurl:Free F1000 Evaluation;http://bit.ly/iT35TCell
linkurl:2. Epigenetic thermometer;http://bit.ly/HSAZFunction Eukaryotes, such as yeast and plants, can sense ambient temperatures at the level of their DNA by evicting or incorporating a histone variant called H2A.Z, which is often associated with gene activation.S.V. Kumar and P.A....
linkurl:3. Fat rat daddies have diabetic daughters;http://bit.ly/FatDadDiabeticDaughter S.F. Ng et al., "Chronic high-fat diet in fathers programs beta-cell dysfunction in female rat offspring," Nature, 467:963-6, 2010. Evaluations by Qingchun Tong and Perry Bickel, Univ Texas; Atsushi Iriki, RIKEN Brain Sci Inst, Japan; Mehboob Hussain, Johns Hopkins Univ; William H Colledge, Univ Cambridge. linkurl:Free F1000 Evaluation;http://bit.ly/FatDadDiabeticDaughter linkurl:4. More complex environments = more sex;http://www.the-scientist.com/news/display/57757/ L. Becks and A.F. Agrawal, "Higher rates of sex evolve in spatially heterogeneous environments," Nature, 468:89-92, 2010. Evaluations by Hanno Seebens and Bernd Blasius, Carl-von-Ossietzky Univ, Germany; Tony D Long, UC Irvine; Richard Frankham, Macquarie Univ, Australia. linkurl:Free F1000 Evaluation;http://bit.ly/HeterogeneousSex linkurl:5. Jumping genes mold mammal brains;http://bit.ly/L1MeCP2 A.R. Muotri et al., "L1 retrotransposition in neurons is modulated by MeCP2," Nature, 468:443-6, 2010. Evaluations by Joachim Messing, Rutgers Univ; Travis Thomson and William Theurkauf, Univ Mass Med Center. linkurl:Free F1000 Evaluation;http://bit.ly/L1MeCP2 linkurl:6. A genome architecture map;http://bit.ly/ChromMap H. Tanizawa et al., "Mapping of long-range associations throughout the fission yeast genome reveals global genome organization linked to transcriptional regulation," Nucleic Acids Res, 38:8164-77, 2010. Evaluation by Richard Maraia, Nat Inst of Child Health and Human Dev; Jurg Bahler, Univ Coll London. linkurl:Free F1000 Evaluation;http://bit.ly/ChromMap linkurl:7. A function for mTORC2;http://bit.ly/mTORC2Func W.J. Oh et al., "mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide," EMBO, 29:3939-51. Evaluations by Jose Mulet and Ramon Serrano, Univ Politecnica de Valencia-CSIC, Spain; Pam Lochhead and Simon Cook, Mol Signalling Lab, UK; Xuemin Wang and Christopher Proud. linkurl:Free F1000 Evaluation;http://bit.ly/mTORC2Func



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