Top 7 in medicine

A snapshot of the most highly ranked articles in medicine and related areas, from Faculty of 1000

Bob Grant
Bob Grant

Bob Grant is Editor in Chief of The Scientist, where he started in 2007 as a Staff Writer.

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linkurl:1. A shared anesthetic binding site; Though general anesthetics are commonly used in medicine, how they work on a molecular level is poorly understood. New research suggests that certain ligand-gated ion channels share a binding site for a couple different general anesthetics; knowledge which could help in the development of new drugs.H. Nury et al., linkurl:"X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel," Nature, 469:428-31, 2011.; Evaluations by Ashley Fiamengo and Roderic Eckenhoff, UPenn; Edward Bertaccini, Stanford Univ Sch Med; Douglas Raines, Mass Gen Hosp; Gregg Homanics Univ Pitt; Stuart Forman, Mass Gen Hosp; Xiangdong Chen and Douglas Bayliss Univ Virg Hlth Sci Cntr. linkurl:Free F1000 Evaluation; linkurl:2. A new C. diff treatment?;
Clostridium difficile colonies
Image: Wikimedia commons, CDC/Dr. Holdeman
The antibiotic vancomycin is the standard treatment for infection by increasingly virulent strains of Clostridium difficile, but recurrence rates are high. A...
T.J. Louie et al., linkurl:" Fidaxomicin versus vancomycin for Clostridium difficile infection," N Engl J Med, 364:422-31, 2011.; Evaluations by Carmel Curtis and Peter Wilson, Univ Coll Lon Hosp; Joyce Popoola, St George's Hosp, UK; Venkataraman Subramanian, Univ Nottingham; Vinay Acharya and Tor Savidge, Univ TX Med Branch. linkurl:Free F1000 Evaluation; linkurl:3. Better ventilation, more transplantable lungs; L. Mascia et al., linkurl:"Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: a randomized controlled trial," JAMA, 304:2620-7, 2010.; Evaluations by Alexander Benson and Ivor Douglas, Univ CO Denver Hlth; Thomas Luecke, Univ Hosp Mannheim, Univ Heidelberg; Claude Guerin, Hospices Civils de Lyon. linkurl:Free F1000 Evaluation; linkurl:4. A mechanism for endocrine tumor troubles; M. Choi et al., linkurl:"K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension," Science, 331:768-72, 2010.; Evaluations by Peter J Fuller, Prince Henry's Inst of Med Rsrch, Australia; Lee S Weinstein, NIDDK/NIH. linkurl:Free F1000 Evaluation; linkurl:5. The microRNA behind hypertension; A. Courboulin et al., linkurl:"Role for miR-204 in human pulmonary arterial hypertension," J Exp Med, 208:535-48, 2011.; Evaluations by Brian Graham, James Hunt and Rubin Tuder, Univ CO Denver; Matthias Brock and Lars Huber, Univ Hospl Zurich. linkurl:Free F1000 Evaluation; linkurl:6. New molecular phenotypes for asthma; P.G. Woodruff et al., linkurl:"T-helper type 2-driven inflammation defines major subphenotypes of asthma," Am J Respir Crit Care Med, 180:388-95, 2009.; Evaluations by Bradley Chipps, Capital Allergy and Respiratory Cntr; Pranab Haldar, Inst Lung Health, UK; Kristie Ross and James Chmiel, Case Western Reserve Univ; Bruce Levy, Brigham & Women's Hosp. linkurl:Free F1000 Evaluation; linkurl:7. Real time tracking of kidney damage; N. Paragas et al., linkurl:"The Ngal reporter mouse detects the response of the kidney to injury in real time," Nat Med, 17:216-22, 2011.; Evaluations by Florian Toegel and Christof Westenfelder, Univ Utah Med Cntrs; Matthieu Legrand, Lariboisière Hosp. linkurl:Free F1000 Evaluation;

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