linkurl:1. A shared anesthetic binding site;http://f1000.com/7989960?key=lsbbqk514qfry3m Though general anesthetics are commonly used in medicine, how they work on a molecular level is poorly understood. New research suggests that certain ligand-gated ion channels share a binding site for a couple different general anesthetics; knowledge which could help in the development of new drugs.H. Nury et al., linkurl:"X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel," Nature, 469:428-31, 2011.;http://www.ncbi.nlm.nih.gov/sites/entrez/21248852?dopt=Abstract&holding=f1000%2Cf1000m Evaluations by Ashley Fiamengo and Roderic Eckenhoff, UPenn; Edward Bertaccini, Stanford Univ Sch Med; Douglas Raines, Mass Gen Hosp; Gregg Homanics Univ Pitt; Stuart Forman, Mass Gen Hosp; Xiangdong Chen and Douglas Bayliss Univ Virg Hlth Sci Cntr. linkurl:Free F1000 Evaluation;http://f1000.com/7989960?key=lsbbqk514qfry3m linkurl:2. A new C. diff treatment?;http://f1000.com/8445961?key=pvp2j4xbpmyphjn
Clostridium difficile colonies
Image: Wikimedia commons, CDC/Dr. Holdeman
The antibiotic vancomycin is the standard treatment for infection by increasingly virulent strains of Clostridium difficile, but recurrence rates are high. A...
T.J. Louie et al., linkurl:" Fidaxomicin versus vancomycin for Clostridium difficile infection," N Engl J Med, 364:422-31, 2011.;http://www.ncbi.nlm.nih.gov/sites/entrez/21288078?dopt=Abstract&holding=f1000%2Cf1000m Evaluations by Carmel Curtis and Peter Wilson, Univ Coll Lon Hosp; Joyce Popoola, St George's Hosp, UK; Venkataraman Subramanian, Univ Nottingham; Vinay Acharya and Tor Savidge, Univ TX Med Branch. linkurl:Free F1000 Evaluation;http://f1000.com/8445961?key=pvp2j4xbpmyphjn linkurl:3. Better ventilation, more transplantable lungs;http://f1000.com/7306957?key=bhhgw5hjk52v9fw L. Mascia et al., linkurl:"Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: a randomized controlled trial," JAMA, 304:2620-7, 2010.;http://www.ncbi.nlm.nih.gov/sites/entrez/21156950?dopt=Abstract&holding=f1000%2Cf1000m Evaluations by Alexander Benson and Ivor Douglas, Univ CO Denver Hlth; Thomas Luecke, Univ Hosp Mannheim, Univ Heidelberg; Claude Guerin, Hospices Civils de Lyon. linkurl:Free F1000 Evaluation;http://f1000.com/7306957?key=bhhgw5hjk52v9fw linkurl:4. A mechanism for endocrine tumor troubles;http://f1000.com/8932956?key=lsc9vyxsgnw0s1m M. Choi et al., linkurl:"K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension," Science, 331:768-72, 2010.;http://www.ncbi.nlm.nih.gov/sites/entrez/21311022?dopt=Abstract&holding=f1000%2Cf1000m Evaluations by Peter J Fuller, Prince Henry's Inst of Med Rsrch, Australia; Lee S Weinstein, NIDDK/NIH. linkurl:Free F1000 Evaluation;http://f1000.com/8932956?key=lsc9vyxsgnw0s1m linkurl:5. The microRNA behind hypertension;http://f1000.com/8598956?key=sz3tz7z9kw1hlty A. Courboulin et al., linkurl:"Role for miR-204 in human pulmonary arterial hypertension," J Exp Med, 208:535-48, 2011.;http://www.ncbi.nlm.nih.gov/sites/entrez/21321078?dopt=Abstract&holding=f1000%2Cf1000m Evaluations by Brian Graham, James Hunt and Rubin Tuder, Univ CO Denver; Matthias Brock and Lars Huber, Univ Hospl Zurich. linkurl:Free F1000 Evaluation;http://f1000.com/8598956?key=sz3tz7z9kw1hlty linkurl:6. New molecular phenotypes for asthma;http://f1000.com/1164541?key=j82bn842jl17rxm P.G. Woodruff et al., linkurl:"T-helper type 2-driven inflammation defines major subphenotypes of asthma," Am J Respir Crit Care Med, 180:388-95, 2009.;http://www.ncbi.nlm.nih.gov/sites/entrez/19483109?dopt=Abstract&holding=f1000%2Cf1000m Evaluations by Bradley Chipps, Capital Allergy and Respiratory Cntr; Pranab Haldar, Inst Lung Health, UK; Kristie Ross and James Chmiel, Case Western Reserve Univ; Bruce Levy, Brigham & Women's Hosp. linkurl:Free F1000 Evaluation;http://f1000.com/1164541?key=j82bn842jl17rxm linkurl:7. Real time tracking of kidney damage;http://f1000.com/8607958?key=6c7p5xnb76230hn N. Paragas et al., linkurl:"The Ngal reporter mouse detects the response of the kidney to injury in real time," Nat Med, 17:216-22, 2011.;http://www.ncbi.nlm.nih.gov/sites/entrez/21240264?dopt=Abstract&holding=f1000%2Cf1000m Evaluations by Florian Toegel and Christof Westenfelder, Univ Utah Med Cntrs; Matthieu Legrand, Lariboisière Hosp. linkurl:Free F1000 Evaluation;http://f1000.com/8607958?key=6c7p5xnb76230hn



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