Top 7 papers in cell biology

Just in time for ASCB -- see the cell biology articles most highly ranked by F1000

Dec 6, 2010
Jef Akst
linkurl:1. Immune response feeds parasite;
Color-enhanced scanning electron micrograph showing Salmonella typhimurium (red) invading cultured human cells.
Image: Wikimedia commons, NIAID, NIH
Salmonella is able to outcompete resident gut microbes by deriving energy from the inflammatory immune response that is supposed to combat the pathogen. S.E. Winter, et al., "Gut inflammation provides a respiratory electron acceptor for Salmonella," linkurl:Nature,; 467:426-9, 2010. Evaluated by Matam Vijay-Kumar and Andrew Gewirtz, Emory University; David Alpers, Washington University School of Medicine; Alexei Kurakin and Roya Khosravi-Far, Beth Israel Deaconess Medical Center; Michael Hensel, University of Osnabrück; Yvonne Sun and Mary O'Riordan, University of Michigan Medical School; Wolf-Dietrich Hardt, Swiss Federal Institute of Technology; James Moir, University of York; Victor Nizet, University of California, San Diego. linkurl:Free F1000 evaluation; linkurl:2. Piezos for pain; A family of proteins, called Piezos, may be components of mechanically activated ion channels which make possible several senses, such as hearing, touch and pain sensation. B. Coste, et al., "Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels," linkurl:Science,; 330:55-60, 2010. Evaluated by M. Moran & D. Kimball, Hydra Biosciences; J. Garcia-Anoveros, Northwestern University; F. Viana, UMH Instituto de Neurociencias; P. Garrity, Brandeis Univ; B. Nilius, KU Leuven. linkurl:Free F1000 evaluation; linkurl:3. New function for noncoding RNAs; Long noncoding RNAs, previously known to silence expression of certain genes, also play a role in gene activation. U.A. Ørom, et al., "Long noncoding RNAs with enhancer-like function in human cells," linkurl:Cell,; 143(1):46-58, 2010. Evaluated by L. Ringrose, Inst of Molecular Biotechnology GmbH; A. Clery, Dominik Theler & F. Allain, ETH; J. Abrams, U of Texas Southwestern Med Cen at Dallas; H. Steinbeisser, Univ of Heidelberg; E. Lara-Pezzi & N. Rosenthal, EMBL. linkurl:Free F1000 evaluation; linkurl:4. Proficient pluripotency; Researchers created synthetic mRNAs that boost the efficiency of human cell reprogramming, marking a significant advance in induced pluripotent stem (iPS) cell technology. L. Warren, et al., "Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA," linkurl:Cell Stem Cell,; 7(5):618-30, 2010. Evaluated by R. Juliano, Univ North Carolina; B. Aranda-Orgilles & I. Aifantis, HHMI/NYU School of Med; K. Maass & G. Fishman, NYU Langone Med Cen; A. Kriegstein, UCSF. linkurl:Free F1000 evaluation; linkurl:5. Details of cell division; complex of proteins crucial for the alignment and separation of chromosomes in dividing cells is directed to the centromeres by the phosphorylating actions of a specific kinase, revealing an important mechanism of cell division that has long escaped scientists. F. Wang, et al., "Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis," linkurl:Science,; 2010 Aug 12 doi: 10.1126/science.1189435. Evaluated by W. Earnshaw, Univ of Edinburgh; E. Avvedimento, Univ Federico II; S. Ems-McClung & C. Walczak, Indiana Univ; R. Medema, Univ. Med Cen Utrecht, Netherlands; K. Lee, NIH. linkurl:Free F1000 evaluation; linkurl:6. Color processing connections; recordings of macaque retinal ganglia allow scientists to map the neural pathways underlying color vision at single-cone resolution, providing insights regarding the functional connectivity of the retinal circuit. G.D. Field, et al., "Functional connectivity in the retina at the resolution of photoreceptors," linkurl:Nature,; 467:673-7, 2010. Evaluated by Richard Born, Harvard Medical School; Bruce Cumming, NEI; Christina Joselevitch and David Zenisek, Yale University School of Medicine; David P Wolfer, University of Zurich. linkurl:Free F1000 evaluation; linkurl:7. Better nuclei isolation; Researchers streamlined a method for tagging nuclei from specific cell types in plants, and purifying them to measure gene expression and chromatin-modification across a variety of tissue types. R.B. Deal and S. Henikoff, "A simple method for gene expression and chromatin profiling of individual cell types within a tissue," linkurl:Dev Cell,; 18:1030-40, 2010. Evaluated by E.S. Dennis, CSIRO; E. Lam, Rutgers Univ; D. Chamovitz, Tel Aviv Univ; K. Schneitz, Technische Univ Munchen; P. Kaufman, U Mass Med School. linkurl:Free F1000 evaluation; The F1000 Top 7 is a snapshot of the highest ranked articles from a 30-day period on Faculty of 1000 Cell Biology, as calculated on December 3, 2010. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit linkurl:;
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