Top 7 worm papers

In light of this month's feature on parasitic worms used to treat disease, we present a snapshot of the most highly ranked articles in related fields from Faculty of 1000

Bob Grant
Bob Grant

Bob Grant is Editor in Chief of The Scientist, where he started in 2007 as a Staff Writer.

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Feb 9, 2011
linkurl:1. Fighters in fat;http://f1000.com/1438956?key=sks77bpwcj55pkx
Larval root-knot nematode, Meloidogyne incognita
Image: Courtesy of the Agricultural Research Service
A new type of immune cell dubbed the "natural helper cell," found around the fat stores of the gut, activates B-cells and produces more Th2-type cytokines than other cells, possibly contributing to allergic immunity, clearance of parasitic worms and wound healing.K. Moro et al., "Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells," linkurl:Nature,;http://www.ncbi.nlm.nih.gov/sites/entrez/20023630?dopt=Abstract&holding=f1000%2Cf1000m 463:540-44, 2010. Evaluated by Avinash Bhandoola, Univ Penn; John Gordon Foster and Steve Ward, Univ Bath, UK; Troy Randall, Univ Rochester; Dale Umetsu, Children's Hosp Boston, Harvard Med Sch; Dhaya Seshasayee and Flavius Martin, Genentech; James Di Santo, Inst Pasteur, France; Richard Locksley, UCSF. linkurl:Free F1000 Evaluation;http://f1000.com/1438956?key=sks77bpwcj55pkx linkurl:2. Worm-bacteria tag team in mice;http://www.f1000biology.com/article/rxym797y26xbn99/id/3941956 Trichuris muris, a common nematode parasite of mice, depends on the host's gut bacteria to help its eggs hatch. Furthermore, T. muris-infected...
K.S. Hayes et al., "Exploitation of the intestinal microflora by the parasitic nematode Trichuris muris," linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/20538949?dopt=Abstract&holding=f1000%2Cf1000m 328:1391-94, 2010. Evaluated by Thomas Nutman, NIH; Richard Locksley, UCSF; Paul Brindley, George Washington Univ. linkurl:Free F1000 Evaluation;http://www.f1000biology.com/article/rxym797y26xbn99/id/3941956 linkurl:3. Pig worms treat Crohn's;http://f1000.com/1022903?key=sf53fwcgzpxdk6b R.W. Summers et al., "Trichuris suis therapy in Crohn's disease," linkurl:Gut,;http://www.ncbi.nlm.nih.gov/sites/entrez/15591509?dopt=Abstract&holding=f1000%2Cf1000m 54:87-90. Evaluated by Etienne Joly, CNRS, France; Steve Ward, Univ Bath, UK; Thomas Nutman, NIH; Paul Brindley, George Washington Univ. linkurl: Free F1000 Evaluation;http://f1000.com/1022903?key=sf53fwcgzpxdk6b linkurl:4. Anti-inflammatory worm eggs;http://www.f1000biology.com/article/5c60g45jzwbw36h/id/1029253 P. Smith et al., "Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity," linkurl:J Exp Med,;http://www.ncbi.nlm.nih.gov/sites/entrez/16301741?dopt=Abstract&holding=f1000%2Cf1000m 202:1319-25, 2005. Evaluated by Richard Grencis, Univ Manchester; Thomas Wynn, NIH; Thomas Nutman, NIH. linkurl:Free F1000 Evaluation;http://www.f1000biology.com/article/5c60g45jzwbw36h/id/1029253 linkurl:5. Achilles heel of immune response?;http://www.f1000biology.com/article/xrmb9ph9bqg5tlh/id/1019072 M. Savignac et al., "Dihydropyridine receptors are selective markers of Th2 cells and can be targeted to prevent Th2-dependent immunopathological disorders," linkurl:J Immunol,; http://www.ncbi.nlm.nih.gov/sites/entrez/15100258?dopt=Abstract&holding=f1000%2Cf1000m 172:5206-12, 2004. Evaluated by Dan Conrad, VA Commonwealth Univ. linkurl:Free F1000 Evaluation;http://www.f1000biology.com/article/xrmb9ph9bqg5tlh/id/1019072 linkurl:6. Worms prevent diabetes in mice;http://www.f1000biology.com/article/jg9mkc998whc7m4/id/1014053 P. Zaccone et al., "Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes," linkurl:Eur J Immunol,;http://www.ncbi.nlm.nih.gov/sites/entrez/12731071?dopt=Abstract&holding=f1000%2Cf1000m 33:1439-49, 2003. Evaluated by Matthias von Herrath; La Jolla Instit for Allergy and Immunology. linkurl:Free F1000 Evaluation;http://www.f1000biology.com/article/jg9mkc998whc7m4/id/1014053 linkurl:7. A macrophage trigger on Th1 cells?;http://www.f1000biology.com/article/8npzg5nm3d8mdqh/id/1005377 L, Monney et al., "Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease," linkurl:Nature,;http://www.ncbi.nlm.nih.gov/sites/entrez/11823861?dopt=Abstract&holding=f1000%2Cf1000m 415:536-41, 2002. Evaluated by Betty Tsao, UCLA. linkurl:Free F1000 Evaluation;http://www.f1000biology.com/article/8npzg5nm3d8mdqh/id/1005377


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