Scientists continue to debate the validity of a highly-cited, controversial 2004 Science paper about a new fat cell protein with insulin-mimetic properties.Last week, Osaka University, which hosted the research, demanded that the researchers retract the paper. In the contested study, Iichiro Shimomura and colleagues at Osaka University Graduate School of Medicine identified a new protein, visfatin, in fat cells and reported that it had insulin-mimetic properties. They found that visfatin lowered blood glucose in vivo in mice and promoted glucose uptake in vitro. Visfatin, the researchers found, is present in visceral adipose tissue, and circulating levels of the protein correlated with fat mass in humans, which raised the possibility of this protein as a potential drug target for type 2 diabetes and other metabolic disorders, the authors wrote. But further research in humans has cast doubt on visfatin as a potential therapy. In the 2004 article, Shimomura and colleagues...
studies have foundrecentShin-ichiro ImaiThe Scientist2005 Diabetes studyThe ScientistScienceScienceClaudio PaganoScienceScienceretractedpublished in Nature MedicineScienceheremail@the-scientist.comSciencehttp://www.the-scientist.com/pubmed/15604363The Scientisthttp://www.the-scientist.com/article/display/22541Curr Opin Lipidolhttp://www.the-scientist.com/pubmed/16531748J Biol Chemhttp://www.the-scientist.com/pubmed/15381699Curr Opin Gastroenterolhttp://www.the-scientist.com/pubmed/17268245http://dbbs.wustl.edu/dbbs/website.nsf/RIB/107B3F3826243E9B86256D4E005B2D3ADiabetes http://www.the-scientist.com/pubmed/16186392Science magazinehttp://www.sciencemag.org/cgi/content/summary/316/5832/1681aJ Clin Endocrinol Metab http://www.the-scientist.com/pubmed/16720654Nature Medicinehttp://www.the-scientist.com/pubmed/15937475Nature Medicine http://www.the-scientist.com/pubmed/15489860
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