New findings may help explain why glioblastomas, one of the most aggressive forms of brain cancer, are often so difficult to treat -- they can feed themselves, by differentiating into the intricate network of blood vessels that nourish the tumor, according to two studies published online today (21 November) in Nature.
Macroscopic pathology of Glioblastoma multiforme Image: Wikimedia commons, Sbrandner
These results may help explain the failure of some anti-angiogenesis therapies used to fight glioblastomas, as well as point to new possible cancer treatments that target tumor-derived angiogenesis. "The general idea is that the vasculature is created by the normal tissue," said cell biologist Angelo Vescovi of the linkurl:Mendel Institute for Genetics in Rome,;http://www.css-mendel.it/home.asp who was not involved in the research. But these papers show that "the tumor itself is actually making its own blood vessels. It's a very different way to look at them."Glioblastomas are noted for their...
R. Wang, et al., "Glioblastoma stem-like cells give rise to tumour endothelium," Nature, doi:10.1038/nature09624, 2010.L. Ricci-Vitiani, et al., " Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells," Nature, doi:10.1038/nature09557, 2010.
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