This webinar, brought to you by DNAnexus and EpiCypher, will be hosted live and available on-demand.
Wednesday, August 26th, 2026
1:00 - 2:00 PM ET
Transcription factors play central roles in establishing cell identity, yet many are expressed across multiple cell types and regulate distinct biological programs. Understanding how these proteins identify the correct genomic targets remains a fundamental challenge in epigenetics and cancer biology. At the same time, advances in automated chromatin profiling are enabling researchers to generate increasingly large epigenomic datasets, creating new opportunities, and new computational challenges, for understanding gene regulation and disease.
In this webinar, brought to you by DNAnexus and EpiCypher, Dr. Aaron D. Viny will present research demonstrating how mutations in the cohesin gene STAG2 alter chromatin accessibility and redirect the erythroid transcription factor GATA1, disrupting normal blood cell development in myelodysplastic syndromes. The presentation will highlight how automated CUT&RUN workflows enabled reproducible profiling of chromatin-bound factors from rare hematopoietic populations and how CUTANA™ Cloud, a data analysis platform that harnesses DNAnexus’s scalable cloud-based bioinformatics infrastructure, enabled and streamlined data analysis, visualization, and biological interpretation.
Then, Dr. Matthew Marunde will discuss how automated CUT&RUN workflows have expanded high-throughput chromatin profiling and how CUTANA™ Cloud leverages DNAnexus's scalable cloud infrastructure to simplify epigenomic data analysis and interpretation.
Together, these presentations will illustrate how integrated experimental and computational approaches are advancing epigenetics research and uncovering new mechanisms of disease.
Topics to be covered
- Automated CUT&RUN for high-throughput chromatin profiling
- Chromatin accessibility and transcription factor targeting
- Cell fate regulation through genotype-to-phenotype mapping
- Epigenetic mechanisms underlying myelodysplastic syndromes
- Cloud-based analysis of large-scale epigenomics datasets
- Integrating experimental and computational workflows for functional genomics
 | Aaron Viny, MD |
 | Matthew R. Marunde, PhD |
 | Theresa Wohlever |
