WIKIMEDIA, GARRETT 222Gene therapy has successfully banished type 1 diabetes in dogs, the first time this treatment has worked to treat the disease in a large animal, according to a study published online in the journal Diabetes earlier this month (February 1).
For the study, Spanish researchers induced diabetes in beagles between 6 months and 1 year old. They then injected the dogs’ skeletal muscles with viruses carrying genes for insulin and glucokinase, an enzyme involved in processing glucose. Following the treatment, the researcher confirmed that the genes had been incorporated into the DNA of the dogs, which were able to regulate their own blood sugar levels without medical help. And when they exercised, they no longer had episodes of hypoglycemia.
Dogs that were injected with viruses carrying only the gene for insulin or only the gene for glucokinase continued to have symptoms of diabetes, indicating that the genes acted in concert.
Following more tests in dogs, the researchers hope to try out the treatment in humans. ...
