Edited by: Thomas W. Durso

'MAJOR IMPORTANCE': Eric Smith evaluated a man shown to be estrogen-resistant.
E.P. Smith, J. Boyd, G.R. Frank, H. Takahashi, R.M. Cohen, B. Specker, T.C. Williams, D.B. Lubahn, K.S. Korach, "Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man," New England Journal of Medicine, 331:1056-61, 1994. (Cited in more than 50 publications as of August 1996)

Comments by Eric P. Smith, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, and Kenneth S. Korach, National Institute of Environmental Health Sciences, Research Triangle Park, N.C.

Estrogen is generally thought to have important effects only on women. But with the publication of this paper, describing the first reported case of estrogen resistance in a human male, researchers demonstrated the importance of the hormone in men.

The subject of this paper, a 28-year-old man who stood at 6 feet, 8...

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