Tinkering With LifeA decade’s worth of engineering-infused biologyIn the late 1990s, a handful of physicists and engineers began to take a greater interest in biology. The Human Genome Project was spitting out more and more gene sequences, but no one knew how all these genes and proteins worked together to create a living, breathing organism. . . .By Jef Akst
Opinion: Evolving EngineeringExploiting the unique properties of living systems makes synthetic biologists better engineers.After 10 years of tinkering with biological circuits, we need to explain the rationale for doing synthetic biology. Despite the musings of some, the field is not limited to toy projects. Recent advances—such as a DNA nanostructure that fights cancer, and a new E. coli genome on its way to multivirus resistance—have demonstrated the discipline’s incredible potential. . . .By George M. Church...
|Rewriting E. coli’s Genetic CodeResearchers use directed evolution to create a bacterial strain that substitutes a synthetic base for thymine.By Sabine Louët|
|Tailor-Made GenomeA method for rapidly replacing stop codons throughout the genetic code of E. coli paves the way for biomanufacturing designer proteins.By Tia Ghose|
|Garage InnovationThe potential costs of regulating synthetic biology must be counted against putative benefits.By Rob Carlson|
|Q&A: Ethics Chair On Synthetic BiologyThe Scientist speaks with the chair of a presidential bioethics commission, which decided this week that synthetic biology should not be too harshly regulated by the US government.By Jef Akst|
|Is the “Synthetic Cell” about Life?A bioethicist explores the soul of Venter’s new life form and of his experiment.By Gregory Kaebnick|
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