Fixing the Flaws in Animal Research

Many preclinical studies carried out in vivo are poorly designed and generate irreproducible data, but efforts to address the problem are on the rise.

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A few years ago, officials at Switzerland’s Federal Food Safety and Veterinary Office approached Hanno Würbel, the head of the animal welfare division at the University of Bern, with the task of examining the quality of experimental design in the country’s animal research. Growing public awareness of the reproducibility crisis in science—which has emerged as researchers discover that a large proportion of scientific results cannot be replicated in subsequent experiments—had put pressure on the government authority to examine this issue, Würbel says. “They wanted to know, what is the situation in Switzerland . . . and is there anything that we need to improve?”

To address this question, Würbel and his colleagues examined scientific protocols in 1,277 applications for licenses to conduct animal research that were submitted to and approved by the Swiss Food Safety and Veterinary Office (FSVO). Their analysis, published in PLOS Biology in ...

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Meet the Author

  • Diana Kwon

    Diana is a freelance science journalist who covers the life sciences, health, and academic life.

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