Mr. Cycle: An Automated PCR Prototype
A 1985 prototype of a semi-automated thermal cycler, hot and cold water baths not included. Credit: Courtesy of The Smithsonian Institution" />A 1985 prototype of a semi-automated thermal cycler, hot and cold water baths not included. Credit: Courtesy of The Smithsonian Institution The "aha" moment and initial experiments in 1983 through which Kary Mullis developed the idea of polymerase chain reaction (PCR) are a well trodden story.1 While Mullis says he immediately realized PCR?s pote
Dec 1, 2006

The "aha" moment and initial experiments in 1983 through which Kary Mullis developed the idea of polymerase chain reaction (PCR) are a well trodden story.
References
1. K. Mullis, "The first polymerase chain reaction," The Scientist, 17(4):11, Feb. 24, 2003. 2. R. Saiki, et al., "Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia," Science, 230:1350-4, 1985. 3. US Patent 4,683,202, filed Oct. 25, 1985; issued July 28, 1987. A second patent (4,683,195, filed Feb. 7, 1986; issued July 28, 1987), with Mullis and others as inventors, further described the technique and claims. 4. US Patent 4,889,818, filed June 17, 1987; issued Dec. 26, 1989.Interested in reading more?
