Menu

H.M.’s Brain, 1953–Present

A temporal lobectomy led to profound memory impairment in a man who became the subject of neuroscientists for the rest of his life—and beyond.

May 1, 2014
Rina Shaikh-Lesko

THE SCARS THAT TAUGHT US: The ventral side of H.M.’s brain shows evidence of the surgical scars left by William Beecher Scoville’s 1956 surgery (A and B), which removed portions of the medial temporal lobe, including much of the hippocampus. Also visible is a mark left by one of the surgical clips (C). During the post-mortem analysis, examiners found an unexpected lesion in the orbitofrontal region (D). The portion of H.M.’s hippocampus that remained after the surgery is not visible in this image. (Scale bar, 1 cm)THE BRAIN OBSERVATORY, JACOPO ANNESEIn 1953, William Beecher Scoville performed an experimental procedure on a 27-year-old man who had exhausted all other medical options for treating his severe epilepsy. A medial temporal lobe resection removed most of the patient’s hippocampus, along with pieces of neighboring regions. It succeeded in nearly eliminating the seizures, but left the young man without the ability to form any new memories.

For the next half century, that patient, known as H.M., would become the most studied man in neuroscience. His memory dysfunction helped neuroscientists understand the critical role the hippocampus plays in receiving, processing, and consolidating sensory input. Nearly 100 researchers have studied him, including Suzanne Corkin, who met H.M. in 1962 when she was a graduate student and went on to work closely with him for nearly five decades. Now a professor emerita at MIT, Corkin describes her long-time subject as gentle, intelligent, and gregarious. It was not until 2008, when he died at 82, that H.M.’s identity and real name, Henry Gustave Molaison, was revealed to the world.

On the night Molaison died, doctors set in motion a plan arranged years in advance to preserve his brain. His body was transported to Massachusetts General Hospital, his head wrapped in cryo-paks that had been stored at the nursing home where Molaison lived. Corkin watched as a neuroradiology team performed high-resolution MRIs late into the night.

A neuropathologist then removed H.M.’s brain from his body, after which it was shipped across the country to The Brain Observatory at the University of California, San Diego. There, Jacopo Annese, who heads the Observatory, led the dissection, imaging, and scanning of H.M.’s brain. “[I was] putting myself in Scoville’s shoes and going back into the brain to understand what happened. It was 1953 again,” says Annese.

Annese, Corkin, and their colleagues reported on the findings of the autopsy in a paper published earlier this year, describing the techniques used to finely slice the brain and digitally scan the slices at a resolution of half a micrometer (Nat Comm, 5:3122, 2014). The examination confirmed earlier MRI results from the 1990s indicating that the entire hippocampus had not been removed. Among the new findings was a small scar where Scoville had lifted the left hemisphere in order to insert his surgical tools deeper in the brain. The team also found a lesion in one of the frontal lobes. “That was a postmortem surprise,” says Corkin. There had been no signs of it on earlier MRI scans, and the research team is investigating the extent of the damage.

Corkin is eager to continue examining H.M.’s brain. She calls this first paper “a promissory note” and believes further histopathological research will provide even more answers. “We’ll really know exactly what was removed, exactly what was left intact, exactly what neuropathological changes are in the brain,” she says.

As a testament to how H.M.’s story galvanized the public’s interest, there have been about 500 requests, many from high school students and teachers, to access the publicly available digital images of H.M.’s brain. Corkin says that’s the way Molaison would have wanted it. “I think he’d feel wonderful about that,” she says. “That was his goal.” 

February 2019

Big Storms Brewing

Can forests weather more major hurricanes?

Marketplace

Sponsored Product Updates

Bio-Rad Releases First FDA-Cleared Digital PCR System and Test for Monitoring Chronic Myeloid Leukemia Treatment Response
Bio-Rad Releases First FDA-Cleared Digital PCR System and Test for Monitoring Chronic Myeloid Leukemia Treatment Response
Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb), a global leader of life science research and clinical diagnostic products, today announced that its QXDx AutoDG ddPCR System, which uses Bio-Rad’s Droplet Digital PCR technology, and the QXDx BCR-ABL %IS Kit are the industry’s first digital PCR products to receive U.S. Food and Drug Administration (FDA) clearance. Used together, Bio-Rad’s system and kit can precisely and reproducibly monitor molecular response to treatment in patients with chronic myeloid leukemia (CML).
Bio-Rad Showcases New Automation Features of its ZE5 Cell Analyzer at SLAS 2019
Bio-Rad Showcases New Automation Features of its ZE5 Cell Analyzer at SLAS 2019
Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb) today showcases new automation features of its ZE5 Cell Analyzer during the Society for Laboratory Automation and Screening 2019 International Conference and Exhibition (SLAS) in Washington, D.C., February 2–6. These capabilities enable the ZE5 to be used for high-throughput flow cytometry in biomarker discovery and phenotypic screening.
Andrew Alliance and Sartorius Collaborate to Provide Software-Connected Pipettes for Life Science Research
Andrew Alliance and Sartorius Collaborate to Provide Software-Connected Pipettes for Life Science Research
Researchers to benefit from an innovative software-connected pipetting system, bringing improved reproducibility and traceability of experiments to life-science laboratories.
Corning Life Sciences to Feature 3D Cell Culture Technologies at SLAS 2019
Corning Life Sciences to Feature 3D Cell Culture Technologies at SLAS 2019
Corning Incorporated (NYSE: GLW) will showcase advanced 3D cell culture technologies and workflow solutions for spheroids, organoids, tissue models, and applications including ADME/toxicology at the Society for Laboratory Automation and Screening (SLAS) conference, Feb. 2-6 in Washington, D.C.