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Volume 16 | Issue 13 | 6 | Jun. 24, 2002 Previous | Next Frontlines MOO over, mouse Photo: ©2001 Jessica Rhiannon Smith When researchers consider disease model options, cows generally remain in the pasture. But a bovine tuberculosis epidemic in the United Kingdom has made the grazers invaluable, not only for studying ways to stymie Mycobacterium bovis, the bovine ver

Eugene Russo
frontlines
Volume 16 | Issue 13 | 6 | Jun. 24, 2002

Frontlines

MOO over, mouse

Photo:
©2001 Jessica Rhiannon Smith

When researchers consider disease model options, cows generally remain in the pasture. But a bovine tuberculosis epidemic in the United Kingdom has made the grazers invaluable, not only for studying ways to stymie Mycobacterium bovis, the bovine version of the tubercle bacilli that causes disease, but the human version, Mycobacterium tuberculosis, as well. At the Fourth World Congress on Tuberculosis, held recently in Washington, DC, tuberculosis (TB) investigator Glyn Hewinson, Department of Bacterial Diseases, Veterinary Laboratories Agency, UK, expounded on the virtues, and liabilities, of using Bossy the cow as a human TB model. Cow pluses: They exhibit a humanlike pathology and immunological response; researchers have a large array of bovine immunological reagents available; calves are immunocompetent early on; vaccines can be tested in the...

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