Edited by: Karen Young Kreeger

Exposing Adenoviruses: Inder Verma and colleagues used nude mice to study immune system and humoral responses during gene therapy.
Y. Dai, E.M. Schwartz, D. Gu, W.-W. Zhang, N. Sarvetnick, I.M. Verma, "Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens for long-term expression," Proceedings of the National Academy of Sciences, 92:1401-5, 1995. (Cited in nearly 60 publications as of December 1996)

Comments by Inder M. Verma, Salk Institute, San Diego

For the last few years, gene therapists have focused their attention on recombinant adenoviruses to deliver genes to cells in vivo. But in several studies, these vectors impart only short-lived expression of the desired therapy. Investigators surmised that the host immune system was responsible for preventing prolonged expression of the foreign genes carried by the adenoviral vectors.

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