Genetic classification of lung tumors

The microscopic distinction of lung cancer into squamous, large cell, small cell, and adenocarcinoma gives essential information about the prognosis of the disease. Two papers in November 20 Proceedings of the National Academy of Sciences, show that DNA microarray studies of crudely dissected lung tumors can be used to detect tumor subtypes that correlate with biological and clinical phenotypes.

Mitchell Garber and colleagues from Stanford University School of Medicine used 24,000-element cDNA microarrays to analyze the global gene expression profiles for 67 human lung tumors of 56 patients. They found specific patterns of gene expression that correspond to the major morphological classes of lung tumors. In addition, the gene expression patterns made possible the subclassification of adenocarcinoma into subgroups that correlated with the degree of tumor differentiation and patient survival (Proc Natl Acad Sci USA 2001, 98:13784–13789).

In a second paper, Arindam Bhattacharjee and colleagues from Harvard Medical School, report ...