K. Nakayama, N. Ishida, M. Shirane, A. Inomata, T. Inoue, N. Shishido, I Hori, D.Y. Loh, K. Nakayama, "Mice lacking p27 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors," Cell, 85:707-20, 1996. (Cited in more than 155 papers since publication)

Comments by Kei-ichi Nakayama, a professor of molecular and cellular biology at Kyushu University, Fukuoka, Japan

Cells proliferate. Cells differentiate. Cells also occasionally stop and take a break from all of that activity. How they get from point A to point B, and how they decide when to take a breather (referred to in technical circles as cell-cycle arrest), is a subject of intense research.

"There has been remarkable progress regarding p27 status and cancer."

--Kei-ichi Nakayama

Many proteins play roles in the process. In particular, a series of cyclin-dependent kinase complexes (CDKs) promote progression from rest phase (G) to the DNA synthesis (S)...

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