DUAL ROLE: Ronald DePinho, a professor at the Albert Einstein College of Medicine, helped to both identify INK4a as a tumor suppressor and to demonstrate its involvement in the Rb and p53 pathways.

M. Serrano, H. Lee, L. Chin, C. Cordon-Cardo, D. Beach, R.A. DePinho, "Role of the INK4a locus in tumor suppression and cell mortality," Cell, 85:27-37, 1996. (Cited in more than 134 publications to date)

Comments by Ronald A. DePinho, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, N.Y.

Tumor suppressors rarely work alone. This paper clarified the role of the INK4a gene and its protein products in tumor suppression and cell mortality or senescence. In the series of papers that followed, researchers confirmed INK4a's role in the pathogenesis of melanoma and demonstrated its intriguing interaction with the tumor suppressors p53 and Rb, genes frequently neutralized in a number of human...

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