Edited by: Ricki Lewis
E. Lander, L. Kruglyak, "Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results," Nature Genetics, 11:241-7, 1995. (Cited in more than 182 publications through August 1997) Comments by Eric Lander, Whitehead/MIT Center for Genome Research

MAKE 'EM LAUGH: Eric Lander used humor to counterbalance heavy use of statistics in his paper on establishing linkage between a complex trait and genetic markers.
For decades, geneticists have attempted to link the genes controlling human traits to chromosomes. At first, linkage data associated inheritance of an abnormal chromosome with a blood type or other detectable trait. In the 1980s, the first restriction fragment-length polymorphism (RFLP) maps correlated phenotypes, such as an inherited disease, to alternative DNA sequences (polymorphisms) that changed cutting sites for restriction enzymes.

Today, the human genome is riddled with so many genetic markers that investigators have ventured beyond the predictably inherited...

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