Edited by: Thomas W. Durso

'LEPTINOMANIA': A paper coauthored by Jose Caro, now of Lilly Research Laboratories, was the second to look at leptin.
R.V. Considine, E.L. Considine, C.J. Williams, M.R. Nyce, S.A. Magosin, T.L. Bauer, E.L. Rosato, J. Colberg, J.F. Caro, "Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity," Journal of Clinical Investigation, 95:2986-8, 1995. (Cited in more than 110 publications as of April 1997)

Comments by Jose F. Caro, Lilly Research Laboratories, Eli Lilly and Co., Indianapolis

This paper, according to investigator Jose F. Caro, helped to usher in "leptinomania." It was the second paper to explore leptin, a protein that helps to control weight by regulating appetite and energy expenditure. In the first (Y.R. Zhang et al., Nature, 372:425-32, 1994), Jeffrey M. Friedman at Rockefeller University in New York cloned a mouse's obese...

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