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Aedes aegypti mosquito that transmits dengue perched on a green leaf.
Genetically Engineered Male Insects Shorten Their Mates’ Lifespans
Male insects carrying venom proteins transferred these to disease-spreading females, reducing their lifespan and providing a pest control method. 
Genetically Engineered Male Insects Shorten Their Mates’ Lifespans
Genetically Engineered Male Insects Shorten Their Mates’ Lifespans

Male insects carrying venom proteins transferred these to disease-spreading females, reducing their lifespan and providing a pest control method. 

Male insects carrying venom proteins transferred these to disease-spreading females, reducing their lifespan and providing a pest control method. 

Genome Editing

2024 Top 10 Innovations logo with a cartoon of a head with a super-imposed light blub
2024 Top 10 Innovations
The Scientist Staff | Dec 13, 2024 | 10+ min read
The latest group of winning technologies has a little something for everyone—from scientists at the lab bench to those in the clinic and even the classroom.
Crystal structure of adeno-associated virus serotype 3B
A Deep Dive into Viral Vectors for Gene Therapy 
Polyplus and The Scientist | Nov 12, 2024 | 1 min read
As the demand for viral vectors rises in new gene therapy approaches, scientists seek ways to optimize their production.
Single cells rendered in 3D
Capturing Complexity Cell by Cell
10x Genomics | Nov 12, 2024 | 1 min read
With the help of single-cell sequencing, researchers characterize biological complexity more fully across a multitude of applications.
An artistic interpretation of CRISPR genome editing showing the cutting and changing of DNA segments.
A Small Genome Editing Nuclease Packs a Big Punch
Sahana Sitaraman, PhD | Oct 30, 2024 | 4 min read
For the past decade, scientists have relied almost exclusively on CRISPR-Cas systems for genome editing. Now, a smaller but equally efficient nuclease is here to compete. 
Improving Gene Therapy Safety with Antibiotic- and Supplement-Free Mini Plasmids
Improving Gene Therapy Safety with Antibiotic- and Supplement-Free Mini Plasmids
The Scientist Staff | Oct 16, 2024 | 1 min read
In this webinar, Cole Cheng and Connie Rich will discuss the advantages of novel miniaturized plasmids for streamlining preclinical and clinical gene therapy development.
Blue and pink DNA helix and human lungs on a blue background.
Nanoparticles Breathe New Life into Lungs
Sneha Khedkar | Oct 15, 2024 | 4 min read
Lipid nanoparticles deliver CRISPR tools directly to lung stem cells, offering new therapeutic avenues for treating genetic diseases.
Lonza
Lonza and Vertex Sign a Long-Term Commercial Supply Agreement for CASGEVY® (exagamglogene autotemcel)
Lonza | Sep 24, 2024 | 2 min read
CASGEVY® is the first cell therapy based on the CRISPR/Cas9 technology, discoverers of which were awarded the Nobel Prize in Chemistry in 2020.
Image of the small intestines and colon within a person with three circular callouts, highlighting different microbes. 
Unlocking the Human Microbiome Mysteries: From Cancer to COVID-19
Laura Tran, PhD | Sep 24, 2024 | 4 min read
The microbiome is a dynamic environment that can give researchers the inside scoop on health and disease.
A conceptual illustration of scissors, which represents a CRISPR-Cas9 complex, cutting a DNA molecule.
Cell Engineering 101: Editing with CRISPR
EditCo | Sep 23, 2024 | 1 min read
Discover how scientists produce CRISPR-edited cell populations.
Two hands holding tweezers and dissecting single points in a DNA sequence.
From CRISPR to Prime Editing: The Evolution of the Genome Editing Revolution
Danielle Gerhard, PhD | Sep 17, 2024 | 5 min read
Even as CRISPR-based tools become a lab staple, scientists strive to tackle the associated technological challenges to improve their efficacy and safety.   
Spying on the Enemy: Using Bacteria to Fight Antibiotic Resistance
Spying on the Enemy: Using Bacteria to Fight Antibiotic Resistance
The Scientist Staff | Sep 6, 2024 | 1 min read
Discover how scientists engineer systems constructed from bacterial components to investigate and combat antimicrobial resistance.
An artist’s representation of the human respiratory system with pink airways on a blue and black background.
A Gene Editing System Corrects Cystic Fibrosis Mutation
RJ Mackenzie | Sep 4, 2024 | 4 min read
An optimized version of prime editing technology raises the possibility of a one-time treatment for cystic fibrosis.
3D illustration of a DNA molecule with sparkling effects symbolizing.
A Prime-Editing Based Approach Records Cellular Genetic History
Maggie Chen | Aug 30, 2024 | 3 min read
Researchers developed a technique, ENGRAM, to keep a running log of the elements that control gene expression in cells. 
Optimizing Gene Editing Experimental Design
Optimizing Gene Editing Experimental Design
The Scientist Staff | Aug 26, 2024 | 1 min read
In this webinar, Jacob Lamberth will discuss the critical variables and strategies for revolutionizing gene editing experiments.
Optimizing Gene Editing Experimental Design
Optimizing Gene Editing Experimental Design
The Scientist Staff | Aug 26, 2024 | 1 min read
In this webinar, Jacob Lamberth will discuss the critical variables and strategies for revolutionizing gene editing experiments.
Conceptual vector image of scientist engage in molecular biology research.
Helper Plasmids Lend a Hand to AAV Production
Sartorius and Polyplus | Aug 21, 2024 | 1 min read
An innovative helper plasmid improves adeno-associated virus quality and infectivity.
Two cells on a purple background. Two mechanisms of gene silencing are shown in the cell on the left, while a double-strand break in a DNA region is shown in the cell on the right.
What’s the Difference Between Gene Knockdown and Gene Knockout?
Mariella Bodemeier Loayza Careaga, PhD | Aug 15, 2024 | 2 min read
There are many techniques that allow scientists to silence a gene, but whether the effect is transient or permanent depends on the type of approach.
Two scientists at a table with two petri dishes of mold. One scientist opens a cloche revealing a meat-like patty made of koji mold.
Mold Burger: Coming Right Up
Laura Tran, PhD | Aug 15, 2024 | 2 min read
From the laboratory to the table, researchers cooked bioengineered fungi into a tempting patty.
Twist
Synthetic Screens, Genes, and De Novo Proteins - A Special Podcast Series
The Scientist and Twist Bioscience | Aug 8, 2024 | 2 min read
In this podcast series, scientists discuss the unique ways they employ synthesized DNA libraries in their research. 
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