Edited by: Steve Bunk
A. Goffeau, B.G. Barrell, H. Bussey, R.W. Davis, B. Dujon, H. Feldmann, F. Galibert, J.D. Hoheisel, C. Jacq, M. Johnston, E.J. Louis, H.W. Mewes, Y. Murakami, P. Philippsen, H. Tettelin, S.G. Oliver, "Life with 6000 genes," Science, 274:546-67, 1996. (Cited in more than 250 papers since publication)

Comments by Steve Oliver , professor, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, United Kingdom, and Andre Goffeau , professor of biochemistry, Unite de Biochimie Physiologique, Universite Catholique de Louvain, Belgium

Steve Oliver
In genetics, reverse engineering has just about had its day. The rise of whole-genome sequen- cing means that researchers no longer are forced to trace back a change in biological function to a specific gene or genes. Instead, studying the form of the complete genome can reveal the functions of individual genes.

This paper had good reason to predict...

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