Technology and approaches for high throughput screening (HTS) have evolved over the last few years, changing HTS workflows and strategies and boosting the alignment of HTS with translational research. In January 2016, PerkinElmer hosted a roundtable in San Diego, CA, to understand trends, best practices, and challenges in the field of HTS. The Scientist facilitated the discussion. Attendees included a group of experts from industry and academia.
Traditional target based HTS is still a primary focus for panel participants, however, they also highlighted trends towards label-free technology and phenotypic screening; in particular, physiologically relevant models that are more predictive had gained traction, such as induced pluripotent stem cells, organoid culture, and 3D culture systems. Interestingly, academia has already seen a shift away from target-based discovery. ...
