Technology and approaches for high throughput screening (HTS) have evolved over the last few years, changing HTS workflows and strategies and boosting the alignment of HTS with translational research. In January 2016, PerkinElmer hosted a roundtable in San Diego, CA, to understand trends, best practices, and challenges in the field of HTS. The Scientist facilitated the discussion. Attendees included a group of experts from industry and academia.

Traditional target based HTS is still a primary focus for panel participants, however, they also highlighted trends towards label-free technology and phenotypic screening; in particular, physiologically relevant models that are more predictive had gained traction, such as induced pluripotent stem cells, organoid culture, and 3D culture systems. Interestingly, academia has already seen a shift away from target-based discovery. Driven by a large volume of stem cell work, phenotypic screening assays have become more common in academia. Some of the major concerns voiced by...

Panelists also identified computational power and data storage as key determinants in the future of HTS. There has been a move towards cloud-based storage and cloud-based software; however, concerns remain over the balance of data accessibility and security. “Data acquisition, analysis, and visualization has always been a challenge for HTS", said Karen Madden, PhD, President PerkinElmer Informatics. "Leveraging the interactivity and analytics power of TIBCO Spotfire and the scalability of the Amazon cloud, we have teamed up with leading screening groups to develop PerkinElmer Signals for Screening to address data management and analysis challenges and help our customers identify actionable insights and achieve robust results.”



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