ASSAY ACE: Aaron Diamond's Alexandra Trkola helped develop an assay that characterized the binding mechanisms of the CCR5 coreceptor, which HIV uses, along with CD4, to gain initial entry into cells.
A. Trkola, T. Dragic, J. Arthos, J.M. Binley, W.C. Olson, G.P. Allaway, C. ChengMayer, J. Robinson, P.J. Maddon, J.P. Moore, "CD4-dependent, antibody- sensitive interactions between HIV-1 and its co-receptor CCR-5," Nature, 384:184-7, 1996. (Cited in more than 165 papers since publication)

Comments by John P. Moore, staff investigator at the Aaron Diamond AIDS Research Center of Rockefeller University in New York and associate professor at Rockefeller University; and Alexandra Trkola, research scientist at the Aaron Diamond AIDS Research Center.

Before recent HIV X-rays illuminated the virus's instruments of invasion, researchers had to find--and assemble--those pieces in the dark.

"We started out not knowing exactly what we were looking for," Alexandra Trkola, a research scientist at the...

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