Horizon Discovery (LSE: HZD) (“Horizon” or “the Company”), a global leader in gene editing and gene modulation technologies, today announces the launch of its new cell line-derived epidermal growth factor receptor (EGFR) Multiplex cell-free DNA (cfDNA) Reference Standard. The new Reference Standard allows laboratories and assay developers to optimize, validate and routinely monitor performance of polymerase chain reaction (PCR)-based tests, next generation sequencing (NGS), and other novel assays designed to detect EGFR mutations from cfDNA.
Horizon’s EGFR Multiplex cfDNA Reference Standard covers ten of the most clinically relevant mutations that predict responsiveness to EGFR tyrosine kinase inhibitors (EGFR-TKIs), including T790M, L858R, C797S and E746-A750del. These variants have been carefully selected to represent a mix of different mutation types, such as SNPs and INDELs, which are challenging for laboratories to detect.
EGFR is a transmembrane protein overexpressed in a variety of cancers, especially in non-small-cell lung cancer (NSCLC), which results in ...
