A Role for Reverse Pharmacology

For this article, James Kling interviewed Masashi Yanagisawa, professor of molecular genetics at the Howard Hughes Medical Institute and University of Texas Southwest Medical Center in Dallas. Data from the Web of Science (ISI, Philadelphia) show that this paper has been cited significantly more often than the average paper of the same type and age. T. Sakurai, A. Amemiya, M. Ishii, I. Matsuzaki, R.M. Chemelli, H. Tanaka, S.C. Williams, J.A. Richardson, G.P. Kozlowski, S. Wilson, J.R.S. Arch, R

James Kling
Mar 19, 2000

For this article, James Kling interviewed Masashi Yanagisawa, professor of molecular genetics at the Howard Hughes Medical Institute and University of Texas Southwest Medical Center in Dallas. Data from the Web of Science (ISI, Philadelphia) show that this paper has been cited significantly more often than the average paper of the same type and age.

T. Sakurai, A. Amemiya, M. Ishii, I. Matsuzaki, R.M. Chemelli, H. Tanaka, S.C. Williams, J.A. Richardson, G.P. Kozlowski, S. Wilson, J.R.S. Arch, R.E. Buckingham, A.C. Haynes, S.A. Carr, R.S. Annan, D.E. McNulty, W.S. Liu, J.A. Terrett, N.A. Elshourbagy, D.J. Bergsma, M. Yanagisawa, "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior," Cell, 92:573-85, Feb. 20, 1998. (Cited in more than 180 papers since publication)

The G-protein coupled receptors (GPCRs) are a well-known family of seven-transmembrane-domain cell surface receptors that respond to a wide variety of...

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