A Tale of Two-Hybrid

Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. Courtesy of Peter UetzPeter Uetz As a graduate student, Peter Uetz investigated embryonic development in mice and chickens, working to explain how deformity relates to the protein formin. Uetz, then working at the European Molecular Biology Laboratory in Heidelberg, Germany, found few answers

Brendan Maher
May 12, 2002
Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.


Courtesy of Peter Uetz

Peter Uetz

As a graduate student, Peter Uetz investigated embryonic development in mice and chickens, working to explain how deformity relates to the protein formin. Uetz, then working at the European Molecular Biology Laboratory in Heidelberg, Germany, found few answers. "It was about that time I realized you cannot explain complicated phenotypes or phenomena just by studying single proteins." Thus began Uetz's interest in creating one of the first protein-protein interaction analyses for a eukaryotic organism. But in moving from one protein to thousands, Uetz had to find something less complex. He turned to budding yeast, Saccharomyces cerevisiae—an organism ripe for proteomic picking. And from the growing proteomics...