AID and Its Impact on Antibody Genetic Alteration

Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. M. Muramatsu et al., "Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme," Cell, 102:553-63, Sept.1, 2000. (Cited in 134 papers) P. Revy et al., "Activation-induced cytidine deaminase (AID) deficiency causes the aut

Josh Roberts
Mar 9, 2003
Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

M. Muramatsu et al., "Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme," Cell, 102:553-63, Sept.1, 2000. (Cited in 134 papers)

P. Revy et al., "Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)," Cell, 102:565-75, Sept. 1, 2000. (Cited in 111 papers)

Antibodies undergo three phases of genetic alteration. Researchers know that perhaps one billion different specificities of human antibodies are created from just 1,000 genes in the germline by shifting and reshifting various segments, called variability (V), diversity (D), and joining (J). These antibodies together recognize nearly every pathogen and toxin the body could encounter. Researchers know,...

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