David A. Cheresh
P.C. Brooks, S. Strömblad, L.C. Sanders, T.L. von Schalscha, R.T. Aimes, W.G. Stetler-Stevenson, J.P. Quigley, D.A. Cheresh, "Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha-vß3," Cell, 85:683-93, 1996. (Cited in more than 155 papers since publication)
Comments by David A. Cheresh, professor of immunology and vascular biology at the Scripps Research Institute in La Jolla, Calif.
Much in the news of late, angiogenesis, the formation of blood vessels during embryogenesis, tissue repair, and the spread of tumors, has been billed as an excellent target for cancer-fighting therapies. Recent studies by the authors of this paper have identified the integrin alpha-vß3 --one of a family of cell-adhesion molecule receptors--as a therapeutic target on angiogenic blood vessels. As part of as-yet-unpublished studies, they've also gone on to evaluate antagonists of this integrin in Phase I and Phase II...