Edited by: Stephen P. Hoffert
T. Fernandes-Alnemri, A. Takahashi, R. Armstrong, J. Krebs, L. Fritz, K.J. Tomaselli, L. Wang, Z. Yu, C.M. Croce, G. Salveson, W.C. Earnshaw, G. Litwack, E.S. Alnemri, "Mch3, a novel human apoptotic cysteine protease highly related to CPP32," Cancer Research, 55:6045-52, 1995. (Cited in more than 140 publications through November 1997)
Comments by Emad S. Alnemri, Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia
In the past five years, knowledge of apoptosis, or programmed cell death, has advanced rapidly and attracted wide attention, as it seems to touch on many areas of cell research. Through apoptosis, the tadpole loses its tail and becomes a frog. In human embryos, apoptosis carves fingers from mitt-like hands. It is a fundamental biological process that plays a critical role in the normal development of multicellular organisms through cellular differentiation and tissue homeostasis.