Biochemistry

Edited by: Steve Bunk M.P. Boldin, T.M. Goncharov, Y.V. Goltsev, D. Wallach, "Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death," Cell, 85:803-15, 1996. (Cited in more than 250 publications as of January 1998) Comments by David Wallach, Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel Photo: Mike Goldberg DIRECT ROUTE: David Wallach of the Weizmann Institute wrote a paper that he says provided the f

Steve Bunk
Feb 1, 1998

Edited by: Steve Bunk
M.P. Boldin, T.M. Goncharov, Y.V. Goltsev, D. Wallach, "Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death," Cell, 85:803-15, 1996. (Cited in more than 250 publications as of January 1998)

Comments by David Wallach, Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel

Photo: Mike Goldberg

DIRECT ROUTE: David Wallach of the Weizmann Institute wrote a paper that he says provided the first evidence that receptors can signal through direct activation of proteases to begin apoptosis.
Cell death and signal transduction are two of the most intensive research fields in biochemistry worldwide. The work described in this paper resulted in findings significant to both those fields. In so doing, it built upon two already-established points of knowledge.

The first point was one to which the laboratory of David Wallach, a professor in the department of biological chemistry...

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