Edited by: Neeraja Sankaran
THERMODYNAMICS TACTICS: Ruth Spolar and M. Thomas Record postulate that conformational changes occur at the binding interface between proteins and their ligands, accounting for changes in heat capacity and entropoy in these reactions.
Comments by Ruth Saecker Spolar, department of chemistry, and M. Thomas Record, Jr., department of biochemistry, University of Wisconsin, Madison
The underlying theme of this paper, according to its authors, is that it provides a basis for understanding the stability and specificity of interactions of proteins with other proteins, nucleic acids, and ligands in thermodynamic terms. They speculate that this approach may be of interest because of its use in relating the molecular structure with function and explaining molecular-recognition events.
"Our focus has been...