Above, from left: Xu Luo, Xiaodong Wang, and Imawati Budihardjo.
Researchers had a good idea of what happens before the death signal reaches the mitochondria. Activation of the Fas and tumor necrosis factor (TNF) death receptors on the cell surface leads to activation of caspase 8 (Casp8). Caspases cleave proteins involved in apoptosis. Researchers also had a handle on cellular events occurring after mitochondria receive the apoptotic signal. The mitochondrial outer membrane becomes permeable to...
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