Edited by: Eugene Russo
A. Merlo, J.G. Herman, L. Mao, D.J. Lee, E. Gabrielson, P.C. Burger, S.B. Baylin, D. Sidransky, "5´ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers," Nature Medicine, 1:686-92, 1995. (Cited in more than 170 papers through June 1997)
Comments by David Sidransky, Johns Hopkins University School of Medicine
GAINING CREDIBILITY: David Sidransky's lab showed that methylation is an important mechanism of gene inactivation.