Edited by Steven Benowitz
R.A. Steinman, B. Hoffman, A. Iro, C. Guillouf, D.A. Liebermann, M.E. Elhouseini, "Induction of p21 (WAF1/CIP1) during differentiation," Oncogene, 9:3389-96, 1994. (Cited in more than 40 publications as of February 1996)
Comments by Richard A. Steinman, University of Pittsburgh Cancer Institute.
CELL CYCLIST: Richard Steinman's cell differentiation research may provide clues to cancer development
Other scientists previously had found that the p21 protein stalls cell division in the early G1 phase of the cell's cycle in response to DNA damage. The effect was controlled by p53, a well-documented tumor-suppressor gene that was thought to activate p21(WAF1) in damaged cells, giving them time...