C.J. Hussussian, J.P. Struewing, A.M. Goldstein, P.A.T. Higgins, D.S. Ally, M.D. Sheahan, W.H. Clark, M.A. Tucker, D.C. Dracopoli, "Germline p16 mutations in familial melanoma," Nature Genetics, 8:15-21, 1994. (Cited in nearly 130 publications as of February 1996)
Comments by Christopher J. Hussussian, Washington University School of Medicine
This paper identifies and describes mutations in the p16 gene in families with malignant melanoma. These mutations affect the balance between the proteins p16 and cyclin D, which play a role in controlling the cell cycle. When the biochemical balance between these two regulators goes awry, abnormal cell growth can result.
|NOT JUST SKIN DEEP: Washington University researcher Christoper J. Hussussian and NIH coworkers identified in the p16 gene in families with a hitory of malnigant melanoma.|