Cancer Prevention

G.S. Omenn, G.E. Goodman, M.D. Thornquist, J. Balmes, M.R. Cullen, A. Glass, J.P. Keogh, F.L. Meyskens Jr., B. Valanis, J.H. Williams Jr., Scott Barnhart, Samuel Hammar, "Effects of a Combination of Beta-Carotene and Vitamin A on Lung and Cardiovascular Disease," New England Journal of Medicine, 334:1150-55, 1996. (Cited in at least 226 publications to date) Comments by Gilbert S. Omenn, Executive Vice President for Medical Affairs, University of Michigan, Ann Arbor HALTING FINDINGS: Michiga

The Scientist Staff
May 10, 1998

G.S. Omenn, G.E. Goodman, M.D. Thornquist, J. Balmes, M.R. Cullen, A. Glass, J.P. Keogh, F.L. Meyskens Jr., B. Valanis, J.H. Williams Jr., Scott Barnhart, Samuel Hammar, "Effects of a Combination of Beta-Carotene and Vitamin A on Lung and Cardiovascular Disease," New England Journal of Medicine, 334:1150-55, 1996. (Cited in at least 226 publications to date)

Comments by Gilbert S. Omenn, Executive Vice President for Medical Affairs, University of Michigan, Ann Arbor


HALTING FINDINGS: Michigan's Gilbert S. Omenn decided to prematurely end a vitamin A and beta-carotene supplementation trial when it was found that subjects receiving daily doses actually had an increased risk of acquiring lung cancer.
Two decades ago, vitamin A and beta-carotene, a plant pigment converted to vitamin A by the liver, earned widespread attention as possible chemopreventative agents against lung cancer. Twenty-one out of 32 observational epidemiology studies found a statistically significant association between low dietary or...

Interested in reading more?

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?