Edited by: Steven Benowitz
REGULATED ACTIVITY: Vanderbilt’s John Exton describes the enzyme phospholipase D’s involvement in the signaling pathway of RhoA.
The enzyme phosholipase D is seemingly everywhere, cellularly speaking, in living systems. Yet scientists aren't completely sure about its precise function. In this paper, the authors describe the enzyme's involvement in the signaling pathway of an important cellular protein, RhoA.
"The enzyme's activity is turned on by hormones, neurotransmitters, and growth factors in mammalian systems," says John H. Exton, a Howard Hughes Medical Institute investigator and a professor of molecular physiology and biophysics at the...