Edited by: Stephen P. Hoffert
S.A. Kliewer, J.M. Lenhard, T.M. Willson, I. Patel, D.C. Morris, J.M. Lehmann, "A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation," Cell, 83:813-9, 1995. (Cited in more than 100 papers through September 1997)
Comments by Jüergen M. Lehmann, Glaxo Wellcome Inc. Research and Development, Research Triangle Park, N.C.
More than 15 million people in the United States suffer from non-insulin dependent diabetes mellitus (NIDDM). No less than 40 million are obese. With so many sufferers, it should be no surprise that this paper, which provides a possible molecular explanation linking these costly and often fatal disorders, is so widely cited.
MISSING LINK: From left, lead scientists Steven Kliewer, Tim Willson, and Jürgen Lehmann discovered a possible causal connection between diabetes and obesity.