Edited by: Thomas W. Durso Comments by Stephen J. Elledge, department of biochemistry, Baylor College of Medicine, and Howard Hughes Medical Institute
S. Matsuoka, M.C. Edwards, C. Bai, S. Parker, P. Zhang, A. Baldini, J.W. Harper, S.J. Elledge, "p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene," Genes & Development, 9:650-62, 1995. (Cited in 130 papers as of April 1997)
Comments by Stephen J. Elledge, department of biochemistry, Baylor College of Medicine, and Howard Hughes Medical InstituteCyclin-dependent kinases (Cdks) are a group of molecules that help to control cellular duplication. According to Stephen J. Elledge, a professor of biochemistry at Baylor College of Medicine and a Howard Hughes Medical Institute investigator, Cdks often receive the information that determines whether a cell will copy itself. "By regulating them, you control cell proliferation," he explains.
SEEKING CKIs: Baylor’s Stephen Elledge helped find a protein that plays a role in Wilms' tumor and Beckwith-Wiedemann syndrome.