Edited by: Karen Young Kreeger
A.G. Batzer, D. Rotin, J.M. Urena, E.Y. Skolnik, J. Schlessinger, "Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor," Molecular and Cellular Biology, 14:5192-201, 1994. (Cited in more than 60 publications as of June 1996)
Comments by Andreas Batzer, T-Cell Sciences Inc., Needham, Mass.
Teasing out the intricate biochemical details of how a hormone or growth factor binds to a cell-surface receptor-in turn activating genes inside the cell's nucleus-has been a hot topic of research in the last few years. This paper describes binding sites for the proteins Grb2 and Shc on the epidermal growth factor receptor (EGFR). Both proteins contain the much-studied SH2 domain, a region of about 100 amino acids that controls portions of a variety of signal transduction pathways.
ON THE SURFACE: Andreas Batzer and colleagues studied Grb2 binding sites